锂预防中血浆和红细胞钠、钾和锂的关系。
The relationships of plasma and erythrocyte sodium, potassium and lithium in lithium prophylaxis.
机构信息
Assistant Professor of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029.
出版信息
Indian J Psychiatry. 1983 Jan;25(1):34-9.
The relationship of intracellular Na+ K+ Li+ to their extracellular concentrations had been studied on 22 cases bipolar affective disorders who had been on prophylactic lithium. 6 of these cases were nonresponders who were admitted repeatedly despite a therapeutic serum lithium values of 0.8-1.1 m moi/L. Parameters measured were Plasma lithium (Lp), Erythrocyte Lithium (Le), Plasma potassium (Kp), Erythrocyte potassium, Ke) Plasma sodium (Nae). Eli had been calculated by using Nerst's equation. Significant correlations have been obtained for dosage and Lp, Lp and Le, and Lp and Le/Lp. There were no significant difference between the responders and non-responders as regards to values of Le, Lp, Nap, Nae, Kp and Ke.
我们对 22 例接受预防性锂盐治疗的双相情感障碍患者的细胞内钠、钾、锂与细胞外浓度的关系进行了研究。其中 6 例患者尽管血清锂浓度在 0.8-1.1mmol/L 之间达到治疗范围，但仍反复发作，被认为是无反应者。所测量的参数包括血浆锂（Lp）、红细胞锂（Le）、血浆钾（Kp）、红细胞钾（Ke）、血浆钠（Nae）。Eli 通过 Nerst 方程计算。锂盐剂量与 Lp、Lp 与 Le、Lp 与 Le/Lp 之间存在显著相关性。在 Le、Lp、Nap、Nae、Kp 和 Ke 方面，反应者和无反应者之间无显著差异。
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