Wells P W, Snodgrass D R
Ann Rech Vet. 1978;9(2):265-7.
The continued presence of antibody to rotavirus in the gut of the neonatal ruminant has been shown to be important in protecting against clinical disease associated with rotavirus infections. This effect is dependant upon the amount of antibody included in the diet. Titres of antibody to rotavirus may be relatively high in ruminant mammary secretions immediately after parturition but decline rapidly over the course of the first day. The influence of vaccination on the titres of antibody, the concentrations of immunoglobulin and their respective of decline in the mammary secretion following parturition has been studied. Ewes vaccinated two to three weeks prior to mating with an inactivated preparation of lamb rotavirus produced colostrum and milk after the subsequent pregnancy which contained significantly higher titres of antibody to the virus than did the mammary secretions from non-vaccinates. The antibody activity appears to be associated with IgG and it is suggested that vaccination may be of value in the alleviation of neonatal diarrhoea associated with rotavirus infection in cattle and sheep.
新生反刍动物肠道中持续存在轮状病毒抗体，已被证明对于预防与轮状病毒感染相关的临床疾病至关重要。这种效果取决于日粮中所含抗体的量。分娩后反刍动物乳腺分泌物中轮状病毒抗体滴度可能相对较高，但在第一天内会迅速下降。研究了疫苗接种对抗体滴度、免疫球蛋白浓度以及分娩后乳腺分泌物中它们各自下降情况的影响。在配种前两到三周用羔羊轮状病毒灭活制剂对母羊进行疫苗接种，在随后怀孕后所产初乳和乳汁中，针对该病毒的抗体滴度显著高于未接种疫苗母羊的乳腺分泌物。抗体活性似乎与IgG相关，并且有人提出疫苗接种对于减轻牛羊中与轮状病毒感染相关的新生腹泻可能具有价值。
