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欧盟减少水泥中六价铬暴露的立法是否有效降低了英国归因于六价铬的过敏性接触性皮炎的发病率?

Has European Union legislation to reduce exposure to chromate in cement been effective in reducing the incidence of allergic contact dermatitis attributed to chromate in the UK?

机构信息

Centre for Occupational and Environmental Health, Health Sciences Group, School of Community-Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK.

出版信息

Occup Environ Med. 2012 Feb;69(2):150-2. doi: 10.1136/oemed-2011-100220. Epub 2011 Aug 17.

Abstract

OBJECTIVE

Hexavalent chromate (chromate) in cement is a well-recognised cause of allergic contact dermatitis (ACD). Consequently in January 2005, following European Union legislation (EU Directive 2003/53/EC), the use or supply of cement containing >2 ppm of chromate was prohibited in the UK (COSHH 2004). This analysis of work-related ill-health surveillance aims to evaluate the effectiveness of this legislation.

METHOD

Changes in the incidence of work-related ACD cases returned to The Health and Occupation Reporting network by dermatologists were analysed taking in to account attribution to chromate and occupation.

RESULTS

There was a significant decline in the incidence of both ACD attributed to chromate (incidence rate ratio 0.48, 95% CI 0.36 to 0.64) and ACD not-attributed chromate (0.76, 95% CI 0.69 to 0.85) between the time period preceding the EU legislation (2002-2004) and the postlegislation period (2005-2009). However, the decline in ACD attributed to chromate was significantly greater (p=0.006). This decline was further increased in workers potentially exposed to cement (incidence rate ratio 0.37, p=0.001). The majority of the decline in incidence occurred during 2005.

CONCLUSION

The timing of this significant decline in the UK incidence of chromate attributed ACD, and the greater decline in workers potentially exposed to cement strongly suggests that the EU Directive2003/53/EC was successful in reducing exposure to chromate in cement in the UK.

摘要

目的

水泥中的六价铬(铬酸盐)是公认的过敏性接触性皮炎(ACD)的原因。因此,2005 年 1 月,根据欧盟法规(欧盟指令 2003/53/EC),英国禁止使用或供应含>2ppm 铬酸盐的水泥(COSHH 2004)。这项针对工作相关疾病监测的分析旨在评估该法规的有效性。

方法

分析皮肤科医生向健康与职业报告网络报告的与工作相关的 ACD 病例的发病率变化,同时考虑归因于铬酸盐和职业因素。

结果

在欧盟法规实施之前(2002-2004 年)和之后(2005-2009 年),归因于铬酸盐的 ACD(发病率比 0.48,95%可信区间 0.36 至 0.64)和非归因于铬酸盐的 ACD(0.76,95%可信区间 0.69 至 0.85)的发病率均显著下降。然而,归因于铬酸盐的 ACD 下降幅度更大(p=0.006)。在可能接触水泥的工人中,这种下降幅度进一步增加(发病率比 0.37,p=0.001)。发病率的下降主要发生在 2005 年。

结论

英国归因于铬酸盐的 ACD 发病率显著下降的时间,以及在可能接触水泥的工人中下降幅度更大,这强烈表明欧盟指令 2003/53/EC 成功地减少了英国水泥中铬酸盐的暴露。

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