脂肪酸衍生物对包膜病毒的灭活作用
Enveloped virus inactivation by fatty acid derivatives.
作者信息
Sands J A, Auperin L D, Reinhardt A
出版信息
Antimicrob Agents Chemother. 1979 Jan;15(1):134-6. doi: 10.1128/AAC.15.1.134.
Abstract
The enveloped bacteriophage phi6 has been shown to be a valuable model system for the preliminary screening of compounds that might be expected to inactivate herpes simplex virus and other enveloped mammalian viruses. A variety of fatty acid derivatives that form fluid micelles in aqueous media have been found to be potent inactivators of phi6. The chemical nature of the polar head group, the length of the alkyl chain(s), and the extent and geometry of unsaturation are all important parameters in determining the antiviral effectiveness of this class of compounds.
摘要
包膜噬菌体phi6已被证明是一种有价值的模型系统，可用于初步筛选可能预期能灭活单纯疱疹病毒和其他包膜哺乳动物病毒的化合物。已发现多种在水性介质中形成流体胶束的脂肪酸衍生物是phi6的有效灭活剂。极性头部基团的化学性质、烷基链的长度以及不饱和度的程度和几何形状都是决定这类化合物抗病毒有效性的重要参数。
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本文引用的文献
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Bacteriophage phi6: a Lipid-Containing Virus of Pseudomonas phaseolicola.噬菌体phi6：一种含脂质的菜豆假单胞菌病毒。
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Inactivation and inhibition of replication of the enveloped bacteriophage phi6 by fatty acids.脂肪酸对包膜噬菌体phi6的灭活及复制抑制作用
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Ultrastructure and life cycle of the lipid-containing bacteriophage phi 6.含脂质噬菌体phi 6的超微结构与生命周期
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Antiviral effects of amphotericin B methyl ester.两性霉素B甲酯的抗病毒作用。
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