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当归中主要成分的生物活性。

Bioactivities of major constituents isolated from Angelica sinensis (Danggui).

机构信息

Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.

出版信息

Chin Med. 2011 Aug 19;6:29. doi: 10.1186/1749-8546-6-29.

DOI:10.1186/1749-8546-6-29
PMID:21851645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3170324/
Abstract

Danggui, also known as Angelica sinensis (Oliv.) Diels (Apiaceae), has been used in Chinese medicine to treat menstrual disorders. Over 70 compounds have been isolated and identified from Danggui. The main chemical constituents of Angelica roots include ferulic acid, Z-ligustilide, butylidenephthalide and various polysaccharides. Among these compounds, ferulic acid exhibits many bioactivities especially anti-inflammatory and immunostimulatory effects; Z-ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects; n-butylidenephthalide exerts anti-inflammatory, anti-cancer and anti-cardiovascular effects.

摘要

当归,也被称为当归(Oliv.)Diels(伞形科),在中国医学中用于治疗月经失调。已经从当归中分离和鉴定出 70 多种化合物。当归根的主要化学成分包括阿魏酸、Z-藁本内酯、丁烯基苯酞和各种多糖。在这些化合物中,阿魏酸具有许多生物活性,特别是抗炎和免疫刺激作用;Z-藁本内酯具有抗炎、抗癌、神经保护和抗肝毒性作用;丁烯基苯酞具有抗炎、抗癌和抗心血管作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/20a4fbe1bcbe/1749-8546-6-29-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/a772d65ad4fd/1749-8546-6-29-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/11106ac7ad24/1749-8546-6-29-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/20a4fbe1bcbe/1749-8546-6-29-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/a772d65ad4fd/1749-8546-6-29-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/11106ac7ad24/1749-8546-6-29-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9422/3170324/20a4fbe1bcbe/1749-8546-6-29-3.jpg

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The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo.天然化合物丁烯基苯酞来源于当归挥发油,能够抑制血管生成在体外和体内。
Angiogenesis. 2011 May;14(2):187-97. doi: 10.1007/s10456-011-9202-8. Epub 2011 Feb 15.
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Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-κB pathway.
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Biomolecules. 2024 Dec 18;14(12):1623. doi: 10.3390/biom14121623.
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Regulatory Effects of Chlormequat Chloride on the Yield and Chemical Composition of Radix.矮壮素对根产量和化学成分的调节作用。
Molecules. 2024 Oct 6;29(19):4725. doi: 10.3390/molecules29194725.
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Origin, evolution, breeding, and omics of Apiaceae: a family of vegetables and medicinal plants.伞形科植物的起源、进化、育种及组学:蔬菜与药用植物家族
Hortic Res. 2022 Apr 11;9:uhac076. doi: 10.1093/hr/uhac076. eCollection 2022.
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