Irish Equine Centre, Johnstown, Naas, Co, Kildare, Ireland.
Ir Vet J. 2007 Dec 1;60(12):728-31. doi: 10.1186/2046-0481-60-12-728.
This study sought to determine whether an increase in resistance of Rhodococcus equi to the antibiotics rifampin and erythromycin occurred over a 10-year period. This was carried out by the use of E test strips for rifampin and erythromycin to determine the MIC (minimum inhibitory concentration) values of Rhodococcus equi to this combination of antibiotics.The findings of this study indicated that there was an increase in resistance of Rhodococcus equi to rifampin and erythromycin over the 10-year period. The MIC for rifampin increased from 0.081 μg/ml in 1996 to 0.187 μg/ml in 2006 and from 0.258 μg/ml for erythromycin during the years prior to 2000 to 0.583 μg/ml in 2006.This finding suggests that there may be a problem in the treatment of Rhodococcus equi infections in foals in the future, particularly as the number of drugs available for treatment of Rhodococcus equi infection is limited because of the intracellular capabilities of this bacterium. Antibiotics used in its treatment have to be able to penetrate the polysaccharide cell wall of Rhodococcus equi as well as the alveolar macrophages in which the bacterium is capable of surviving.
本研究旨在确定在10年期间马红球菌对利福平和红霉素的耐药性是否增加。这是通过使用利福平和红霉素的E试验条来确定马红球菌对这种抗生素组合的最低抑菌浓度（MIC）值来进行的。本研究结果表明，在10年期间马红球菌对利福平和红霉素的耐药性有所增加。利福平的MIC从1996年的0.081μg/ml增加到2006年的0.187μg/ml，红霉素的MIC从2000年之前的0.258μg/ml增加到2006年的0.583μg/ml。这一发现表明，未来在治疗幼驹马红球菌感染方面可能存在问题，特别是由于这种细菌具有细胞内生存能力，可用于治疗马红球菌感染的药物数量有限。用于治疗的抗生素必须能够穿透马红球菌的多糖细胞壁以及该细菌能够存活的肺泡巨噬细胞。
