Kimoto T, Kurimura T
Arch Virol. 1979;59(1-2):59-67. doi: 10.1007/BF01317895.
Difference in antibody responses between varicella and herpes zoster was reconfirmed by complement fixation (CF) test and by platelet aggregation (PA) test. Rise in PA antibody level was observed only in patients with herpes zoster, but not in patients with varicella, while the increase in CF antibody was demonstrated in both types of the diseases. Among 235 healthy children, CF antibody was detected in 42 children and out of these 25 also had PA antibody. Sera of 116 individuals who were vaccinated with a live vaccine comprised of varicella-herpes zoster virus (VZV) were tested for CF and PA antibodies. Within six months after vaccination, 81.3 per cent of the vaccinees demonstrated the rise in CF antibody alone, and only one vaccinee possessed low level of PA antibody. Six months to 1 year after vaccination, CF antibody in 12 out of 13 vaccinees fell to undetectable level. Later than 1 year after vaccination, 9 out of 28 vaccinees possessed CF antibody. Two out of these 9 vaccinees also had PA antibody. The PA antigens prepared from viruses isolated either from a varicella patient or a herpes zoster patient responded similarly to the sera of herpes zoster patients, but no response was detected with sera of varicella patients. PA and CF antibody titers of herpes zoster patients showed a high degree of correlation.
通过补体结合（CF）试验和血小板聚集（PA）试验再次证实了水痘和带状疱疹患者抗体反应的差异。仅在带状疱疹患者中观察到PA抗体水平升高，而水痘患者中未观察到，而两种疾病患者的CF抗体均有增加。在235名健康儿童中，42名儿童检测到CF抗体，其中25名儿童也有PA抗体。对116名接种了由水痘 - 带状疱疹病毒（VZV）组成的活疫苗的个体血清进行CF和PA抗体检测。接种疫苗后六个月内，81.3%的接种者仅表现出CF抗体升高，只有一名接种者PA抗体水平较低。接种疫苗后六个月至一年，13名接种者中有12名的CF抗体降至无法检测的水平。接种疫苗一年后，28名接种者中有9名拥有CF抗体。这9名接种者中有2名也有PA抗体。从水痘患者或带状疱疹患者分离出的病毒制备的PA抗原对带状疱疹患者血清的反应相似，但水痘患者血清未检测到反应。带状疱疹患者的PA和CF抗体滴度显示出高度相关性。
