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“结核合并糖尿病患者”:糖尿病对结核病的影响及其对全球结核病控制的威胁。

'The tubercular diabetic': the impact of diabetes mellitus on tuberculosis and its threat to global tuberculosis control.

机构信息

Brighton and Sussex Medical School, Brighton.

出版信息

Clin Med (Lond). 2011 Aug;11(4):344-7. doi: 10.7861/clinmedicine.11-4-344.

DOI:10.7861/clinmedicine.11-4-344
PMID:21853830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5873743/
Abstract

The incidence and prevalence of diabetes mellitus (DM) is rapidly increasing across the globe. Tuberculosis (TB), meanwhile, remains a significant problem in low and middle income countries fuelled by high rates of HIV/AIDS. This article explores the long recognised but underappreciated connection between the two, revealing that DM makes a substantial contribution to the burden of incident TB around the world and may also worsen TB severity and treatment outcome. The dual management of the diseases may be challenging but must be addressed, both in low and high income settings, because the rising worldwide diabetes burden poses a threat to global TB control.

摘要

糖尿病(DM)的发病率和患病率在全球范围内迅速上升。与此同时,结核病(TB)仍然是中低收入国家的一个重大问题,其原因是艾滋病毒/艾滋病的高发病率。本文探讨了长期以来被认识到但却被低估的两者之间的联系,结果表明,DM 对全球新发病例 TB 的负担有很大贡献,而且可能使 TB 的严重程度和治疗结果恶化。两种疾病的双重管理可能具有挑战性,但必须加以解决,无论是在低收入还是高收入环境中,因为全球糖尿病负担的增加对全球结核病控制构成了威胁。

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本文引用的文献

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International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes.国际专家委员会关于糖化血红蛋白检测在糖尿病诊断中作用的报告。
Diabetes Care. 2009 Jul;32(7):1327-34. doi: 10.2337/dc09-9033. Epub 2009 Jun 5.
2
Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis.糖尿病对活动性肺结核患者治疗结局的影响。
Am J Trop Med Hyg. 2009 Apr;80(4):634-9.
3
Profile of tuberculosis patients progressing to death, city of São Paulo, Brazil, 2002.2002年巴西圣保罗市结核病患者死亡情况剖析
Rev Saude Publica. 2008 Oct;42(5):805-12. doi: 10.1590/s0034-89102008000500004.
4
Risk factors for multidrug-resistant tuberculosis in a tuberculosis unit in Madrid, Spain.西班牙马德里一家结核病治疗中心耐多药结核病的危险因素
Eur J Clin Microbiol Infect Dis. 2009 Apr;28(4):325-30. doi: 10.1007/s10096-008-0627-y. Epub 2008 Oct 2.
5
Type 2 diabetes and multidrug-resistant tuberculosis.2型糖尿病与耐多药结核病
Scand J Infect Dis. 2008;40(11-12):888-93. doi: 10.1080/00365540802342372.
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Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies.糖尿病会增加活动性肺结核的风险:对13项观察性研究的系统评价
PLoS Med. 2008 Jul 15;5(7):e152. doi: 10.1371/journal.pmed.0050152.
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Impact of type 2 diabetes on manifestations and treatment outcome of pulmonary tuberculosis.2型糖尿病对肺结核临床表现及治疗结果的影响。
Epidemiol Infect. 2009 Feb;137(2):203-10. doi: 10.1017/S0950268808000782. Epub 2008 Jun 18.
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Adapting the DOTS framework for tuberculosis control to the management of non-communicable diseases in sub-Saharan Africa.使结核病控制的直接督导下的短程化疗(DOTS)框架适用于撒哈拉以南非洲地区的非传染性疾病管理。
PLoS Med. 2008 Jun 10;5(6):e124. doi: 10.1371/journal.pmed.0050124.
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Sputum conversion at the end of intensive phase of Category-1 regimen in the treatment of pulmonary tuberculosis patients with diabetes mellitus or HIV infection: An analysis of risk factors.糖尿病或HIV感染的肺结核患者在1类方案强化期结束时的痰菌转阴情况:危险因素分析
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The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus.γ干扰素在2型糖尿病患者结核病发病风险增加中所起的作用。
Eur J Clin Microbiol Infect Dis. 2008 Feb;27(2):97-103. doi: 10.1007/s10096-007-0395-0. Epub 2007 Oct 26.