黄曲霉毒素 B1 在印度北部人群原发性肝癌发病中的作用。
Role of aflatoxin B1 as a risk for primary liver cancer in north Indian population.
机构信息
Department of Medicine, Maulana Azad Medical College, University of Delhi, New Delhi, India.
出版信息
Clin Biochem. 2011 Oct;44(14-15):1235-40. doi: 10.1016/j.clinbiochem.2011.07.017. Epub 2011 Aug 10.
OBJECTIVES
The present study was designed to determine whether aflatoxin B1 (AFB1) exposure has any role to play in hepatocellular carcinoma (HCC) patients from northern India.
DESIGN AND METHODS
A total of 266 HCC patients and 251 patients of chronic liver disease without-HCC were enrolled into the study. All samples were screened for serological markers for hepatitis B and C infections and levels of AFB1 in food and urine samples.
RESULTS
A threefold (OR=3.43) and five-fold (OR=5.47) increased risk of HCC was observed amongst HBV infection and AFB1-levels in food and urine samples, respectively. However, a non-significant risk was observed with respect to HCV infection (OR=1.27) and alcohol consumption (OR=1.18). A threefold (OR=3.15) increased risk of HCC was observed amongst cases of non-viral etiology with respect to urinary AFB1.
CONCLUSION
The data provides an exposure and disease risk information for establishing intervention studies to diminish the impact of aflatoxin exposure in Indian population.
目的
本研究旨在确定黄曲霉毒素 B1（AFB1）暴露是否与印度北部的肝细胞癌（HCC）患者有关。
设计和方法
共纳入 266 例 HCC 患者和 251 例无 HCC 的慢性肝病患者。所有样本均检测乙型肝炎和丙型肝炎感染的血清标志物以及食物和尿液样本中 AFB1 的水平。
结果
HBV 感染和食物及尿液样本中 AFB1 水平分别使 HCC 的发病风险增加了三倍（OR=3.43）和五倍（OR=5.47）。然而，HCV 感染（OR=1.27）和饮酒（OR=1.18）与 HCC 风险的相关性无统计学意义。与病毒性病因相比，非病毒性病因的 HCC 发病风险增加了三倍（OR=3.15），尿液中的 AFB1 水平与此相关。
结论
该数据提供了暴露和疾病风险信息，可用于开展干预研究，以减少印度人群中黄曲霉毒素暴露的影响。
Zotero 插件