Levy Gary, Lucidi Richard S
Tripler Army Medical Center, Honolulu, USA.
Hawaii Med J. 2011 May;70(5):97-8.
Ovarian Hyperstimulation syndrome (OHSS) is one of the most serious complications of controlled ovarian hyperstimulation. Recent prospective data revealed possible increased prevalence of thrombophilia markers in women who develop severe ovarian hyperstimulation syndrome (OHSS).
A 26-year-old nulliparous woman underwent ovarian stimulation for in vitro fertilization with recombinant follicle stimulating hormone and developed severe OHSS. She was screened for hereditary and inherited thrombophilia markers and was found to be homozygous for MTHFR mutation and had decreased antithrombin levels.
This case adds to the limited information that there may be an association between women who develop severe ovarian hyperstimulation syndrome and an increased prevalence of underlying thrombophilia markers. If further research demonstrates a cost effective strategy, screening for those markers may identify women who are at a higher risk for development of severe ovarian hyperstimulation syndrome.
卵巢过度刺激综合征（OHSS）是控制性卵巢刺激最严重的并发症之一。最近的前瞻性数据显示，发生严重卵巢过度刺激综合征（OHSS）的女性中，血栓形成倾向标志物的患病率可能增加。
一名26岁未生育的女性接受重组促卵泡激素进行体外受精的卵巢刺激，并发严重OHSS。她接受了遗传性和先天性血栓形成倾向标志物筛查，结果发现其亚甲基四氢叶酸还原酶（MTHFR）突变呈纯合状态，抗凝血酶水平降低。
该病例补充了有限的信息，即发生严重卵巢过度刺激综合征的女性与潜在血栓形成倾向标志物患病率增加之间可能存在关联。如果进一步的研究证明有经济有效的策略，对这些标志物进行筛查可能会识别出发生严重卵巢过度刺激综合征风险较高的女性。
