Ren Yahao, Li Yanxi, Zhao Yue, Yu Fei, Zhan Zhipeng, Yuan Yuan, Yang Jun
Department of Nutrition and Food hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
Wei Sheng Yan Jiu. 2011 Jul;40(4):495-7.
To investigate the effects of resveratrol on serum and liver lipids in C57BL/6J mice.
30 male C57BL/6J mice were randomly assigned to the following three groups: control group given a normal diet, high-fat diet group and resveratrol group (22.5 mg/kg BW) were given high fat diet. the resveratrol were dissolved in 0.5% sodium carboxymethyl cellulose and were given to the Resveratrol group by intragastric administration. The levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), the levels of TG and TC in liver, and the pathological changes of liver were measured after the treatment lasted for 8 weeks.
The serum TC, LDL-C, HDL-C levels of high-fat diet and resveratrol groups were higher than those of control group (P < 0.05), and the serum TC and LDL-C levels of high-fat diet were also higher than those of resveratrol group (P < 0. 05). But the serum TG levels of high-fat diet and resveratrol groups were lower than those of control group (P < 0.05). The TC content of liver in high-fat diet group were higher than those of control and resveratrol groups (P < 0.05).
The TC content in C57BL/6J mice can be decreased by resveratrol (22.5 mg/kg BW).
