Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Reprod Biol Endocrinol. 2011 Aug 23;9:119. doi: 10.1186/1477-7827-9-119.
Ovarian cysts are a common cause for gynecological surgery. However, some cysts are a direct result of endocrine disorders and do not require surgery. This report describes an unusual case in which persistent ovarian cysts are associated with primary hypothyroidism in a young woman. The data were collected by history-taking, physical examination, laboratory tests, ultrasound, magnetic resonance imaging and a histo-pathological study. In addition, the exons of the gene encoding the human follicle-stimulating hormone receptor were sequenced.
The patient had markedly elevated levels of thyroid-stimulating hormone and follicle-stimulating hormone and an enlarged pituitary gland. After treatment with thyroid hormone replacement, regression of the enlarged pituitary and the ovarian cysts was observed. The possible mechanisms of the pathophysiology are discussed below.
It is necessary to consider hypothyroidism and other endocrine disorders in the differential diagnosis of adult patients with ovarian multiple cyst formation in order to prevent inadvertent ovarian surgery.
卵巢囊肿是妇科手术的常见原因。然而，有些囊肿是内分泌失调的直接结果，不需要手术。本报告描述了一例罕见病例，一名年轻女性的持续性卵巢囊肿与原发性甲状腺功能减退症有关。数据通过病史采集、体格检查、实验室检查、超声、磁共振成像和组织病理学研究收集。此外，还对编码人卵泡刺激素受体的基因的外显子进行了测序。
患者的甲状腺刺激激素和卵泡刺激激素水平显著升高，且垂体增大。甲状腺激素替代治疗后，观察到增大的垂体和卵巢囊肿消退。以下讨论了病理生理学的可能机制。
在鉴别诊断成年患者的卵巢多发性囊肿形成时，有必要考虑甲状腺功能减退症和其他内分泌紊乱，以防止意外的卵巢手术。
