Department of Psychiatry, School of Medicine, University of Michigan Ann Arbor, MI, USA.
Front Neuroanat. 2011 Jul 29;5:47. doi: 10.3389/fnana.2011.00047. eCollection 2011.
Striatal-enriched protein tyrosine phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer's disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function. We review the mechanisms by which STEP contributes to the etiology of these and other neuropsychiatric disorders. These findings suggest that disruptions in STEP activity may be a common mechanism for cognitive impairments in diverse illnesses.
富含纹状体的蛋白酪氨酸磷酸酶（STEP）最近被牵连到几种伴有严重认知障碍的神经精神疾病中，包括阿尔茨海默病、精神分裂症和脆性 X 综合征。通过该模型可知，STEP 通常会阻碍突触增强的发展，而 STEP 活性的中断会导致异常的突触功能。我们综述了 STEP 导致这些和其他神经精神疾病病因的机制。这些发现表明，STEP 活性的中断可能是多种疾病认知障碍的共同机制。
