Department of Hygiene and Preventive Medicine (Zoonoses), Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Food Chem Toxicol. 2011 Nov;49(11):2816-9. doi: 10.1016/j.fct.2011.08.008. Epub 2011 Aug 16.
Occurrence of aflatoxin M(1) (AFM(1)) in infant formula milk powder (IFMP) and maternal breast milk (MBM) was investigated as a risk factor affects the health of newborns in Egypt. A total of 125 IFMP and 125 MBM samples were collected and examined for the presence of AFM(1) using competitive ELISA test. The results indicated that the relative risk (RR) of exposure to AFM(1) via consumption of MBM was higher than IFMP (RR; 1.6, 95%CI; 1.28-2.03, p=0.0001). The mean concentrations of AFM(1) were significantly differed (p<0.0001) between MBM (74.413 ± 7.070 ng/l) and IFMP (9.796 ± 1.036 ng/l). High frequency distributions were detected within the range of 5-25 ng/l and >50-100 ng/l in IFMP and MBM, respectively. The average daily exposure of newborns to AFM(1) via consumption of MBM and IFMP was 52.684 and 8.170 ng, respectively, with a significant difference at p<0.0001. Consumption of raw milk by lactating mothers exhibited a significant correlation (p<0.0001) with the presence of AFM(1) in their milk. In conclusion, this work established a pioneering concept that AFM(1) may be considered as an etiological factor for a novel foodborne zoonosis identified as Aflatoxicosis M(1).
本研究旨在探讨婴儿配方奶粉（IFMP）和产妇母乳（MBM）中黄曲霉毒素 M1（AFM1）的存在情况，以及其作为影响埃及新生儿健康的风险因素。共采集了 125 份 IFMP 和 125 份 MBM 样本，采用竞争酶联免疫吸附试验（ELISA）检测 AFM1 的存在情况。结果表明，通过食用 MBM 接触 AFM1 的相对风险（RR）高于 IFMP（RR；1.6，95%CI；1.28-2.03，p=0.0001）。AFM1 的平均浓度在 MBM（74.413±7.070ng/L）和 IFMP（9.796±1.036ng/L）之间存在显著差异（p<0.0001）。IFMP 和 MBM 中均检测到 5-25ng/L 和>50-100ng/L 范围内的高频分布。通过食用 MBM 和 IFMP，新生儿每日摄入 AFM1 的平均值分别为 52.684ng 和 8.170ng，差异有统计学意义（p<0.0001）。哺乳期母亲食用生牛奶与母乳中存在 AFM1 呈显著相关（p<0.0001）。综上所述，本研究首次提出了一个概念，即 AFM1 可能被认为是一种新型食源性动物传染病——黄曲霉毒素 M1 的病因。
