Caputo R, Monti M, Motta S, Barbareschi M, Tosti A, Serri R, Rigoni C
Department of Dermatology, University of Milan, Italy.
Br J Dermatol. 1990 Apr;122 Suppl 35:97-103. doi: 10.1111/j.1365-2133.1990.tb16133.x.
An open clinical study was undertaken to evaluate the anti-photoageing efficacy of topical tretinoin. A length of cream of approximately 1 cm was applied to the face daily in the evening for 6 months: during month 1 of therapy 0.01% tretinoin cream was administered; 0.025% was given during month 2; and 0.05% was given in months 3-6. The clinical symptoms of photoageing (coarse wrinkling, fine wrinkling, skin thinning, mottled hyperpigmentation, laxity and xerosis) were evaluated before and after therapy. A total of 19.1% of patients withdrew from the study; only 5.6% were for treatment-related reasons. At the end of the treatment period all the clinical parameters, except xerosis, were improved. The amount of improvement varied, but only 4.2% of patients failed to show any improvement. Tolerability was excellent in 51.4% of patients, good in 44.4% and fair in 4.2%, and compliance was excellent in 47.0% of patients, good in 48.5% and fair in 4.5%. Tolerability and compliance were improved by applying the same amount of cream each day but increasing the concentration of tretinoin over the 6-month period. Silicone skin replicas of the same area of skin taken before and after treatment, analysed by scanning electron microscopy, profilometry and computer image analysis, showed a decrease in the width of wrinkles, and an improvement in skin texture and follicle density.
开展了一项开放性临床研究，以评估外用维甲酸的抗光老化疗效。每晚将约1厘米长的乳膏涂抹于面部，持续6个月：治疗第1个月使用0.01%维甲酸乳膏；第2个月使用0.025%；第3至6个月使用0.05%。在治疗前后评估光老化的临床症状（粗皱纹、细皱纹、皮肤变薄、斑驳色素沉着、皮肤松弛和皮肤干燥）。共有19.1%的患者退出研究；仅5.6%是出于与治疗相关的原因。在治疗期结束时，除皮肤干燥外，所有临床参数均得到改善。改善程度各不相同，但只有4.2%的患者未显示任何改善。51.4%的患者耐受性极佳，44.4%良好，4.2%一般；47.0%的患者依从性极佳，48.5%良好，4.5%一般。通过在6个月期间每天涂抹相同量的乳膏但增加维甲酸浓度，耐受性和依从性得到改善。通过扫描电子显微镜、轮廓测定法和计算机图像分析对治疗前后相同皮肤区域的硅胶皮肤复制品进行分析，结果显示皱纹宽度减小，皮肤质地和毛囊密度得到改善。
