Monti M, Caputo R
Institute of Clinical Dermatology, Milan, Italy.
J Int Med Res. 1990;18 Suppl 3:35C-40C.
A total of 89 patients (mean age 42 years) with clinical signs of photo-ageing were evaluated in an open study to determine the clinical efficacy and tolerance of topical tretinoin therapy. Each evening for 6 months about 1 cm of cream containing tretinoin was applied to the face. Patient compliance and tolerance were maximized by gradually increasing the tretinoin concentration in the cream over the treatment period: 0.01% tretinoin for 1 month, then 0.025% for 1 month and finally 0.05% for 4 months. By the end of the 6 months' treatment period, 95.8% of patients showed improvement in the clinical symptoms of photo-ageing (coarse and fine wrinkling, skin thinning, mottled hyperpigmentation and laxity), except for xerosis. During treatment, 17 (19.1%) patients withdrew from the study, in five (5.6%) this was due to treatment-related side-effects. Patient compliance was rated as excellent in 47.0% of cases, good in 48.5% and fair in 4.5%; tolerability was excellent in 51.4% of cases, good in 44.4% and fair in 4.2%. Improvements were confirmed by scanning electron microscopy, computerized profilometry and computerized image analysis of skin replicas of the same areas taken before and after treatment, with a reduction in width and depth of wrinkles, improved skin texture and increased follicle density.
在一项开放性研究中，对89例有光老化临床症状的患者（平均年龄42岁）进行了评估，以确定外用维甲酸治疗的临床疗效和耐受性。在6个月的时间里，每晚将约1厘米含维甲酸的乳膏涂抹于面部。在治疗期间，通过逐渐增加乳膏中维甲酸的浓度来使患者的依从性和耐受性最大化：0.01%维甲酸使用1个月，然后0.025%使用1个月，最后0.05%使用4个月。在6个月的治疗期结束时，95.8%的患者光老化的临床症状（粗皱纹和细皱纹、皮肤变薄、斑驳性色素沉着和皮肤松弛）有所改善，但皮肤干燥症除外。治疗期间，17例（19.1%）患者退出研究，其中5例（5.6%）是由于与治疗相关的副作用。47.0%的病例患者依从性被评为优秀，48.5%为良好，4.5%为一般；51.4%的病例耐受性优秀，44.4%为良好，4.2%为一般。通过扫描电子显微镜、计算机轮廓测定法以及对治疗前后同一部位皮肤复制品的计算机图像分析证实了病情的改善，皱纹的宽度和深度减小，皮肤质地改善，毛囊密度增加。
