Caputo R, Monti M, Rigoni C, Pinelli S, Motta S, Barbareschi M
First Department of Dermatology and Paediatric Dermatology, University of Milan, Italy.
Br J Dermatol. 1992 Sep;127 Suppl 41:51-3. doi: 10.1111/j.1365-2133.1992.tb16990.x.
In a previously reported study on the anti-photoageing effects of topical tretinoin, the following regimen produced good patient compliance: 0.01% for 1 month, 0.025% for 1 month; and 0.05% for 4 months. The majority of patients (60/89) enrolled in the initial study continued to apply the cream to the face, and a further 140 patients were enrolled for a long-term study (mean duration 2 years). The prolonged study showed that 91.4% of patients used tretinoin in an attempt to slow down skin aging, and 8.6% sought subjective skin benefits. Of the 163 patients who completed the study, 58.8% sought an improvement of wrinkles, 30.1% skin trophism and 14.7% reduced pigmentation. The product was used throughout the year by 66.9% of patients, but 8.0% stopped using it during the summer. A daytime moisturizing cream was required by 77.9% of patients, and 82.8% used a sunscreen in the summer. Tretinoin was applied to other areas of the body by 63.8% of patients.
在先前一项关于外用维甲酸抗光老化作用的研究中，以下方案患者依从性良好：0.01%使用1个月，0.025%使用1个月，0.05%使用4个月。初始研究纳入的大多数患者（60/89）继续将该乳膏涂抹于面部，另外140名患者被纳入一项长期研究（平均持续时间2年）。长期研究表明，91.4%的患者使用维甲酸以试图减缓皮肤衰老，8.6%的患者寻求主观的皮肤改善效果。在完成研究的163名患者中，58.8%的患者寻求改善皱纹，30.1%的患者寻求改善皮肤营养状态，14.7%的患者寻求减少色素沉着。66.9%的患者全年使用该产品，但8.0%的患者在夏季停止使用。77.9%的患者需要一款日间保湿霜，82.8%的患者在夏季使用防晒霜。63.8%的患者将维甲酸涂抹于身体的其他部位。
