King Caroline C, Jamieson Denise J, Wiener Jeffrey, Cu-Uvin Susan, Klein Robert S, Rompalo Anne M, Shah Keerti V, Sobel Jack D
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, NCCDPHP, DRH, 4770 Buford Highway, Mailstop K-34, Atlanta, GA 30341, USA.
Infect Dis Obstet Gynecol. 2011;2011:319460. doi: 10.1155/2011/319460. Epub 2011 Aug 16.
To evaluate associations between common vaginal infections and human papillomavirus (HPV).
Data from up to 15 visits on 756 HIV-infected women and 380 high-risk HIV-uninfected women enrolled in the HIV Epidemiology Research Study (HERS) were evaluated for associations of bacterial vaginosis, trichomoniasis, and vaginal Candida colonization with prevalent HPV, incident HPV, and clearance of HPV in multivariate analysis.
Bacterial vaginosis (BV) was associated with increased odds for prevalent (aOR = 1.14, 95% CI: 1.04, 1.26) and incident (aOR = 1.24, 95% CI: 1.04, 1.47) HPV and with delayed clearance of infection (aHR = 0.84, 95% CI: 0.72, 0.97). Whereas BV at the preceding or current visit was associated with incident HPV, in an alternate model for the outcome of incident BV, HPV at the current, but not preceding, visit was associated with incident BV.
These findings underscore the importance of prevention and successful treatment of bacterial vaginosis.
评估常见阴道感染与人类乳头瘤病毒（HPV）之间的关联。
对参与HIV流行病学研究（HERS）的756名感染HIV的女性和380名未感染HIV的高危女性进行了多达15次访视的数据评估，在多变量分析中评估细菌性阴道病、滴虫病和阴道念珠菌定植与HPV流行、HPV新发和HPV清除之间的关联。
细菌性阴道病（BV）与HPV流行（调整后比值比[aOR]=1.14，95%置信区间[CI]：1.04，1.26）和新发（aOR=1.24，95%CI：1.04，1.47）的几率增加相关，且与感染清除延迟（调整后风险比[aHR]=0.84，95%CI：0.72，0.97）相关。虽然前次或本次访视时的BV与HPV新发相关，但在新发BV结局的另一种模型中，本次而非前次访视时的HPV与新发BV相关。
这些发现强调了预防和成功治疗细菌性阴道病的重要性。
