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妊娠期静脉血栓栓塞症的诊断与预防策略

Strategies for diagnosis and prevention of venous thromboembolism during pregnancy.

作者信息

Bagaria Shalini Jain, Bagaria V B

机构信息

Health Care Research and Innovation Division, Origyn Clinic, Indirapuram, Ghaziabad 201014, India.

出版信息

J Pregnancy. 2011;2011:206858. doi: 10.1155/2011/206858. Epub 2011 Jul 21.

DOI:10.1155/2011/206858
PMID:21869932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3159016/
Abstract

Pregnancy and the postpartum period have an increased incidence of venous thromboembolism (VTE). The condition is unique during this period for several reasons. Primarily, because there is complexity in diagnosing this condition in view of altered physiology and preexisting edema in pregnancy and also because there are restrictions on the use of certain drugs and a need for vigilant monitoring of anticoagulant activities of drugs during the period. The problem is compounded and assumes the highest order of significance since two lives are involved and all the investigations and management done should also take into account the potential adverse effects on the foetus. In order to prevent the development of VTE during pregnancy, sound clinical evaluation for risk factors, risk stratification, and optimal use of resource both mechanical and pharmacological is necessary. This paper details strategies in preventing development of deep vein thrombosis and treatment of VTEs.

摘要

怀孕和产后时期静脉血栓栓塞(VTE)的发病率增加。由于多种原因,这种情况在此期间具有独特性。首先,鉴于孕期生理变化和已有水肿,诊断这种疾病存在复杂性,而且在此期间某些药物的使用受到限制,并且需要密切监测药物的抗凝活性。由于涉及两条生命,问题变得更加复杂且具有最高级别的重要性,所有的检查和管理都应考虑对胎儿的潜在不良影响。为了预防孕期VTE的发生,对危险因素进行合理的临床评估、风险分层以及机械和药物资源的优化利用是必要的。本文详细阐述了预防深静脉血栓形成和治疗VTE的策略。

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本文引用的文献

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Use of imaging for investigation of suspected pulmonary embolism during pregnancy and the postpartum period.孕期及产后疑似肺栓塞的影像学检查应用
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Venous thromboembolic disease and pregnancy.静脉血栓栓塞性疾病与妊娠
N Engl J Med. 2008 Nov 6;359(19):2025-33. doi: 10.1056/NEJMra0707993.
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A negative D-dimer does not exclude venous thromboembolism (VTE) in pregnancy.D - 二聚体阴性并不能排除妊娠期静脉血栓栓塞症(VTE)。
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