Hess R F, Mansouri B, Thompson B
McGill Vision Research, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Strabismus. 2011 Sep;19(3):110-8. doi: 10.3109/09273972.2011.600418.
To develop a treatment for amblyopia based on re-establishing binocular vision.
A novel procedure is outlined for measuring and reducing the extent to which the fixing eye suppresses the fellow amblyopic eye in adults with amblyopia. We hypothesize that suppression renders a structurally binocular system, functionally monocular.
We demonstrate that strabismic amblyopes can combine information normally between their eyes under viewing conditions where suppression is reduced by presenting stimuli of different contrast to each eye. Furthermore we show that prolonged periods of binocular combination leads to a strengthening of binocular vision in strabismic amblyopes and eventual combination of binocular information under natural viewing conditions (stimuli of the same contrast in each eye). Concomitant improvement in monocular acuity of the amblyopic eye occurs with this reduction in suppression and strengthening of binocular fusion. Additionally, stereoscopic function was established in the majority of patients tested. We have implemented this approach on a headmounted device as well as on a handheld iPod.
This provides the basis for a new treatment of amblyopia, one that is purely binocular and aimed at reducing suppression as a first step.
研发一种基于重建双眼视觉的弱视治疗方法。
概述了一种用于测量和减少成人弱视患者中注视眼对弱视眼抑制程度的新程序。我们假设这种抑制使得一个结构上的双眼系统在功能上成为单眼系统。
我们证明，通过向每只眼睛呈现不同对比度的刺激来减少抑制的观看条件下，斜视性弱视患者能够正常地整合双眼之间的信息。此外，我们表明长时间的双眼整合会导致斜视性弱视患者双眼视觉增强，并最终在自然观看条件下（每只眼睛中对比度相同的刺激）实现双眼信息的整合。随着这种抑制的减少和双眼融合的增强，弱视眼的单眼视力也会相应提高。此外，大多数接受测试的患者都建立了立体视觉功能。我们已经在头戴式设备以及手持iPod上实施了这种方法。
这为一种新的弱视治疗方法提供了基础，该方法完全基于双眼，并且第一步旨在减少抑制。
