Department of Periodontology, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
Arch Oral Biol. 2012 Jan;57(1):60-5. doi: 10.1016/j.archoralbio.2011.07.012. Epub 2011 Aug 25.
The goal of the present study was to evaluate the histopathologic and morphometric effects of systemic boric acid in a rat periodontitis model.
Twenty-four Wistar rats were divided into three groups of eight animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the mandibular first molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups.
The ratio of presence of inflammatory cell infiltration (ICI) and osteoclast number in the LO group was significantly higher than that of the NL and BA groups (p<0.05). The ratio of presence of osteoblastic activity in the LO group was significantly lower than that of the NL and BA groups (p<0.05). Alveolar bone loss was also significantly higher in the LO group compared to the BA and NL groups (p<005).
This study has demonstrated that systemic administration of boric acid reduced periodontal inflammation and alveolar bone loss in periodontal disease in rats.
本研究旨在评估系统性硼酸对大鼠牙周炎模型的组织病理学和形态计量学影响。
将 24 只 Wistar 大鼠分为三组，每组 8 只：未结扎组（NL）、结扎组（LO）和结扎并用硼酸处理组（BA）（每天 3mg/kg，共 11 天）。用 4/0 丝线将下颌第一磨牙的龈下位置结扎；11 天后处死大鼠，临床测量牙槽骨水平变化，组织学检查评估组织学变化，以评估各组之间的差异。
LO 组的炎症细胞浸润（ICI）和破骨细胞数量存在的比例明显高于 NL 和 BA 组（p<0.05）。LO 组成骨细胞活性存在的比例明显低于 NL 和 BA 组（p<0.05）。LO 组的牙槽骨丢失也明显高于 BA 和 NL 组（p<005）。
本研究表明，系统性给予硼酸可减少大鼠牙周炎的牙周炎症和牙槽骨丢失。
