Pediatric Dentistry Department, Ahmet Kelesoglu Dentistry Faculty, Karamanoglu Mehmetbey University, Karaman, Turkey.
Pendik Oral and Dental Health Center, İstanbul, Turkey.
Sci Rep. 2024 Jun 15;14(1):13861. doi: 10.1038/s41598-024-64904-w.
For successful root canal treatment, adequate chemomechanical instrumentation to eliminate microorganisms and pulp tissue is crucial. This study aims to assess the organic tissue dissolving activity of various irrigation solutions on bovine tooth pulp tissue. 40 extracted bovine mandibular anterior teeth (n = 10) were used for the study. Bovine pulp pieces (25 ± 5 mg) were placed in 1.5 ml Eppendorf tubes. Each tooth pulp sample was then covered with 1.5 ml of different irrigation solutions, dividing them into four groups: Group 1 with freshly prepared 5% Boric acid, Group 2 with 5% NaOCl, Group 3 with Irritrol, and Group 4 with Saline. Samples were left at room temperature for 30 min, then dried and reweighed. The efficacy of tissue dissolution ranked from highest to lowest was found to be NaOCl, Boric Acid, Irritrol, and saline (p < 0.05). It was observed that the decrease in the NaOCl group was greater than the decrease in the Irritrol and saline groups, and the decrease in the Boric acid group was significantly greater than the decrease in the saline group (p < 0.05). It also emphasizes the need for future studies to further investigate the effects of Irritrol and Boric Acid on tissue dissolution.
为了实现成功的根管治疗，彻底清除微生物和牙髓组织的化学机械清创至关重要。本研究旨在评估各种冲洗液对牛牙牙髓组织的有机组织溶解活性。使用 40 颗从下颌前磨牙中提取的牙齿（n=10）进行了研究。将 25±5mg 的牛牙髓组织放置在 1.5ml 的 Eppendorf 管中。然后，将每个牙髓样本分别用 1.5ml 不同的冲洗液覆盖，将其分为四组：第 1 组为新制备的 5%硼酸，第 2 组为 5%次氯酸钠，第 3 组为 Irritrol，第 4 组为生理盐水。将样本在室温下放置 30 分钟，然后干燥并重新称重。组织溶解效果从高到低依次为：次氯酸钠、硼酸、Irritrol 和生理盐水（p<0.05）。观察到，次氯酸钠组的减少量大于 Irritrol 和生理盐水组，硼酸组的减少量明显大于生理盐水组（p<0.05）。这也强调了需要进一步研究 Irritrol 和硼酸对组织溶解的影响。
