Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Planta Med. 2012 Jan;78(1):86-9. doi: 10.1055/s-0031-1280127. Epub 2011 Sep 16.
A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana led to the isolation and identification of three new triterpenoids, 2 α,3 α,19 α-trihydroxy-urs-12-en-24-formyl-28-oic acid (1), 2 α,3 β,21 α-trihydroxy-urs-12-en-28-oic acid ( 2), and 3 β-acetyloxy-1-oxo-olean-12-en-28-oic acid (3), along with seven known triterpenoids (4-10). The structures of these new compounds were determined through spectral analysis, including extensive 2D-NMR data. The new compounds 1-3 showed significant cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cell lines with IC(50) values ranging from 7.17 to 48.73 µM.
在对朝鲜小檗树干进行基于生物测定的分离和化学成分研究后，分离并鉴定出了三种新的三萜类化合物，2α,3α,19α-三羟基-熊-12-烯-24-甲酰基-28-羧酸（1）、2α,3β,21α-三羟基-熊-12-烯-28-羧酸（2）和 3β-乙酰氧基-1-氧代-齐墩果-12-烯-28-羧酸（3），以及 7 种已知的三萜类化合物（4-10）。这些新化合物的结构通过光谱分析确定，包括广泛的 2D-NMR 数据。新化合物 1-3 对 A549、SK-OV-3、SK-MEL-2 和 HCT-15 人肿瘤细胞系表现出显著的细胞毒性，IC50 值范围为 7.17-48.73µM。
