Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea.
Mol Med Rep. 2011 Nov-Dec;4(6):1107-13. doi: 10.3892/mmr.2011.568. Epub 2011 Aug 22.
This study investigated the anti-obesity properties of an extract of Geranium thunbergii (GTE) in high-fat diet-induced obese mice. GTE treatment significantly reduced body weight, adipose tissue mass, adipocyte size, as well as serum triglyceride, total cholesterol and low-density lipoprotein-cholesterol levels in obese mice compared to high-fat diet-fed mice. It also decreased serum leptin levels and increased adiponectin levels. The serum levels of aspartate transaminase, alanine transaminase, blood urea nitrogen and creatinine were not significantly changed in GTE-treated mice compared to serum levels in normal diet and high-fat diet-fed mice. Furthermore, GTE suppressed the mRNA levels of sterol regulatory element-binding protein 1c, peroxisome proliferator-activated receptor γ, adipocyte fatty acid-binding protein and fatty acid synthase in the adipose tissues of obese mice. These results suggest that GTE ameliorated high-fat diet-induced obesity by altering the adipokine levels and downregulating the expression of transcription factors and lipogenic enzymes involved in lipid metabolism.
本研究探讨了香叶天竺葵（GTE）提取物在高脂饮食诱导肥胖小鼠中的抗肥胖特性。与高脂饮食喂养的小鼠相比，GTE 处理显著降低了肥胖小鼠的体重、脂肪组织质量、脂肪细胞大小以及血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平。它还降低了血清瘦素水平并增加了脂联素水平。与正常饮食和高脂饮食喂养的小鼠相比，GTE 处理的小鼠血清中天冬氨酸转氨酶、丙氨酸转氨酶、血尿素氮和肌酐水平没有明显变化。此外，GTE 抑制了肥胖小鼠脂肪组织中固醇调节元件结合蛋白 1c、过氧化物酶体增殖物激活受体 γ、脂肪细胞脂肪酸结合蛋白和脂肪酸合酶的 mRNA 水平。这些结果表明，GTE 通过改变脂肪因子水平和下调参与脂质代谢的转录因子和脂肪生成酶的表达来改善高脂饮食诱导的肥胖。
