Geok Chin Tan, Masir Noraidah, Noor Hussin Hamidah, Mohd Sidik Shiran, Boon Cheok Lee, Yean Thean
Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur.
Malays J Pathol. 2011 Jun;33(1):47-51.
Myeloid sarcoma (MS) is a rare extramedullary myeloid tumour. It has been reported in various sites, including lymph node, bone, skin, soft tissue, various organs and the CNS. It may precede or occur concurrently with acute myeloid leukemia. Urinary bladder involvement is extremely uncommon. We report a 70-year-old female who had MS of the urinary bladder, presented with frank and persistent hematuria associated with lower abdominal pain. She subsequently had tumour seeding in the abdominal skin via percutaneous suprapubic catheter. Tumours from both the urinary bladder and skin showed immature cells that were immunoreactive toward LCA (focal), MPO (strong), CD99 (weak) and CD117 (weak). Summary of cases in the literature is presented. The potential of its misdiagnosis and the useful markers for the diagnosis of MS are discussed.
髓系肉瘤（MS）是一种罕见的髓外髓性肿瘤。它已在包括淋巴结、骨骼、皮肤、软组织、各种器官和中枢神经系统在内的不同部位被报道。它可能先于急性髓系白血病出现或与之同时发生。膀胱受累极为罕见。我们报告一名70岁女性，患有膀胱髓系肉瘤，表现为明显且持续的血尿并伴有下腹痛。随后，她通过经皮耻骨上导管在腹部皮肤出现肿瘤播散。膀胱和皮肤的肿瘤均显示未成熟细胞，这些细胞对LCA（局灶性）、MPO（强阳性）、CD99（弱阳性）和CD117（弱阳性）呈免疫反应性。文中呈现了文献中的病例总结。讨论了其误诊的可能性以及用于诊断髓系肉瘤的有用标志物。
