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印度宫颈癌防控现状与HPV流行病学概述

The present scenario of cervical cancer control and HPV epidemiology in India: an outline.

作者信息

Senapathy J Giftson, Umadevi P, Kannika P S

机构信息

Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, India.

出版信息

Asian Pac J Cancer Prev. 2011;12(5):1107-15.

Abstract

OBJECTIVE

To give a clear picture with epidemiological evidence about the present scenario of cervical cancer control and HPV in India.

DESIGN

Review of published studies, concentrating on recent systematic reviews, meta-analyses and large prospective studies.

CONCLUSIONS AND RECOMMENDATIONS

Cervical cancer is unique among cancers in that it can largely be prevented through screening and removal of precursor lesions. It is the second most common cancer among women worldwide and is the most common malignancy in developing countries, particularly in India. Nowadays, cervical screening for women is necessary because there are no signs and symptoms of cervical precancers. The establishment of a prevention program is urgently required considering both screening and vaccination. But most women in India do not have access to effective screening programmes. It has been estimated that in India, even with a major effort to expand cytology services, it will not be possible to screen even one-fourth of the population once in a lifetime in the near future. New HPV vaccines will also help prevent HPV infection and the precancerous changes that lead to cervical cancer. The focus on detection and prevention of cervical cancer must be emphasized in a highly populated country like India to prevent its extensive spread.

摘要

目的

利用流行病学证据清晰呈现印度宫颈癌防控及人乳头瘤病毒(HPV)的现状。

设计

对已发表研究进行综述,重点关注近期的系统评价、荟萃分析及大型前瞻性研究。

结论与建议

宫颈癌在癌症中独具特点,很大程度上可通过筛查及切除癌前病变来预防。它是全球女性中第二常见的癌症,也是发展中国家最常见的恶性肿瘤,在印度尤为如此。如今,由于宫颈癌前病变没有体征和症状,对女性进行宫颈筛查很有必要。考虑到筛查和疫苗接种,迫切需要建立预防项目。但印度大多数女性无法获得有效的筛查项目。据估计,在印度,即便大力扩充细胞学服务,在不久的将来也不可能让四分之一的人口一生中接受一次筛查。新型HPV疫苗也将有助于预防HPV感染及导致宫颈癌的癌前病变。在印度这样人口众多的国家,必须强调对宫颈癌的检测和预防,以防止其广泛传播。

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