随着时间的推移，疾病活动通过心理中介对功能限制的影响：强直性脊柱炎患者的 12 个月纵向研究。
The contribution of disease activity on functional limitations over time through psychological mediators: a 12-month longitudinal study in patients with ankylosing spondylitis.
机构信息
Department of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Becker B-131, Los Angeles, CA 90048, USA.
出版信息
Rheumatology (Oxford). 2011 Nov;50(11):2087-92. doi: 10.1093/rheumatology/ker274. Epub 2011 Aug 28.
OBJECTIVES
To explore whether helplessness, internality and depression would mediate the relationship between disease activity and functional limitations in patients with AS in a 12-month longitudinal study.
METHODS
A total of 294 participants with AS meeting modified New York criteria completed clinical and psychological assessments at 6-month intervals. Psychological measures evaluated helplessness, depression and internality. Path analysis evaluated the direct and indirect effects of baseline disease activity on 12-month functional limitations via the psychological measures of helplessness, internality and depression at 6 months.
RESULTS
Baseline disease activity demonstrated direct and indirect effects on 12-month functional limitations. Helplessness and depression, but not internality, served as mediators of the relationship between disease activity and functional limitations.
CONCLUSION
Higher baseline disease activity predicted greater functional limitations at 12 months through helplessness and depression. Our findings suggest that helplessness and depression may constitute future treatment targets in reducing functional limitations in patients with AS.
目的
在一项为期 12 个月的纵向研究中，探索无助感、内在性和抑郁是否在 AS 患者的疾病活动与功能受限之间起中介作用。
方法
共有 294 名符合改良纽约标准的 AS 患者，每 6 个月进行一次临床和心理评估。心理测量评估无助感、抑郁和内在性。路径分析评估了基线疾病活动对 12 个月功能受限的直接和间接影响，通过 6 个月时无助感、内在性和抑郁等心理测量指标来实现。
结果
基线疾病活动对 12 个月的功能受限有直接和间接的影响。无助感和抑郁，而不是内在性，是疾病活动与功能受限之间关系的中介因素。
结论
更高的基线疾病活动通过无助感和抑郁预测了 12 个月时更大的功能受限。我们的研究结果表明，无助感和抑郁可能是减少 AS 患者功能受限的未来治疗靶点。
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