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本文引用的文献

1
Melioidosis: a clinical overview.类鼻疽病：临床概述。
Br Med Bull. 2011;99:125-39. doi: 10.1093/bmb/ldr007. Epub 2011 May 9.
2
The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study.类鼻疽病的流行病学和临床谱：来自达尔文前瞻性研究 20 年的 540 例病例。
PLoS Negl Trop Dis. 2010 Nov 30;4(11):e900. doi: 10.1371/journal.pntd.0000900.
3
Increasing incidence of human melioidosis in Northeast Thailand.泰国东北部人类类鼻疽病发病率上升。
Am J Trop Med Hyg. 2010 Jun;82(6):1113-7. doi: 10.4269/ajtmh.2010.10-0038.
4
In vitro activity of doripenem against Burkholderia pseudomallei.多黏菌素B对类鼻疽伯克霍尔德菌的体外活性。
Antimicrob Agents Chemother. 2009 Jul;53(7):3115-7. doi: 10.1128/AAC.00893-08. Epub 2009 Apr 13.
5
Variations in ceftazidime and amoxicillin-clavulanate susceptibilities within a clonal infection of Burkholderia pseudomallei.在一株克隆性感染的类鼻疽伯克霍尔德菌中头孢他啶和阿莫西林-克拉维酸敏感性的差异
J Clin Microbiol. 2009 May;47(5):1556-8. doi: 10.1128/JCM.01657-08. Epub 2009 Mar 18.
6
A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand.在泰国进行的粒细胞集落刺激因子治疗类鼻疽所致严重脓毒症的随机对照试验。
Clin Infect Dis. 2007 Aug 1;45(3):308-14. doi: 10.1086/519261. Epub 2007 Jun 15.
7
Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis.两项关于单用头孢他啶与头孢他啶联合甲氧苄啶-磺胺甲恶唑治疗严重类鼻疽病的随机对照试验。
Clin Infect Dis. 2005 Oct 15;41(8):1105-13. doi: 10.1086/444456. Epub 2005 Sep 2.
8
Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei.嗜麦芽窄食单胞菌临床分离株对甲氧苄啶/磺胺甲恶唑的耐药性
J Antimicrob Chemother. 2005 Jun;55(6):1029-31. doi: 10.1093/jac/dki151. Epub 2005 May 10.
9
Comparison of gatifloxacin, moxifloxacin and ciprofloxacin for treatment of experimental Burkholderia pseudomallei infection.加替沙星、莫西沙星和环丙沙星治疗实验性伯克霍尔德菌感染的比较。
J Antimicrob Chemother. 2005 Apr;55(4):523-7. doi: 10.1093/jac/dki039. Epub 2005 Feb 24.
10
Comparison of the susceptibilities of Burkholderia pseudomallei to meropenem and ceftazidime by conventional and intracellular methods.采用传统方法和细胞内方法比较伯克霍尔德菌对美罗培南和头孢他啶的敏感性。
Antimicrob Agents Chemother. 2004 Aug;48(8):2999-3005. doi: 10.1128/AAC.48.8.2999-3005.2004.

二十年来泰国东北部临床分离鲍氏不动杆菌的抗菌药物耐药性调查。

Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand.

机构信息

Mahidol-Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand.

出版信息

Antimicrob Agents Chemother. 2011 Nov;55(11):5388-91. doi: 10.1128/AAC.05517-11. Epub 2011 Aug 29.

DOI:10.1128/AAC.05517-11
PMID:21876049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3195054/
Abstract

A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n = 8), amoxicillin-clavulanic acid (n = 4), or both drugs (n = 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

摘要

在泰国东北部进行的一项为期 21 年的研究调查了用于治疗类鼻疽病的注射用抗菌药物的耐药性，发现 4021 例患者中有 24 例（0.6%）对头孢他啶（n=8）、阿莫西林克拉维酸（n=4）或两种药物（n=12）有一个或多个分离物耐药。有两例在入院时就已发现，其余患者在开始抗菌治疗后平均 15 天发现。未检测到对碳青霉烯类药物的耐药性。这些发现支持当前针对类鼻疽病的处方推荐。