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对头孢他啶耐药性的基因组洞察：发现A172T突变和富含GC的回文重复序列促进重复和扩增。

Genomic insights into ceftazidime resistance in : discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating duplication and amplification.

作者信息

Tuanyok Apichai, Nakajima Chie, Noll Tiernan, Khan Md Siddiqur Rahman, Khrongsee Pacharapong, Yowell Charles A, Xiao Yu-Ping, Wuthiekanun Vanaporn, Chantratita Narisara, Heine Henry, Subramaniam Kuttichantran, Suzuki Yasuhiko, Limmathurotsakul Direk, Mergia Ayalew

机构信息

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.

出版信息

Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0022025. doi: 10.1128/aac.00220-25. Epub 2025 Jul 21.

DOI:10.1128/aac.00220-25
PMID:40689768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12326997/
Abstract

Ceftazidime (CAZ) resistance in , the causative agent of melioidosis, complicates treatment in endemic regions. This study identified a novel A172T mutation and other known mutations as critical contributors to CAZ resistance in a large Thai strain collection. Frequent gene duplication and amplification of , likely driven by Palindromic GC-Rich Repeat Sequences, highlights the urgent need for rapid diagnostics and optimized treatment strategies to manage this life-threatening disease effectively.

摘要

类鼻疽杆菌（引起类鼻疽病的病原体）对头孢他啶（CAZ）耐药，使流行地区的治疗变得复杂。本研究在一大批泰国菌株中鉴定出一种新的A172T突变以及其他已知突变，这些是导致对CAZ耐药的关键因素。可能由富含GC的回文重复序列驱动的类鼻疽杆菌频繁基因复制和扩增，凸显了迫切需要快速诊断和优化治疗策略以有效管理这种危及生命疾病的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/f69edf1e4634/aac.00220-25.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/cbe2c4114433/aac.00220-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/5ebea532257a/aac.00220-25.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/f69edf1e4634/aac.00220-25.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/cbe2c4114433/aac.00220-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/5ebea532257a/aac.00220-25.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8078/12326997/f69edf1e4634/aac.00220-25.f003.jpg

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本文引用的文献

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Drug Resist Updat. 2024 Sep;76:101121. doi: 10.1016/j.drup.2024.101121. Epub 2024 Jul 14.
2
Synchronous detection of and its ceftazidime resistance mutation based on RNase-HII hydrolysis combined with lateral flow strip assay.基于 RNase-HII 水解和侧流带检测的 及其头孢他啶耐药突变的同步检测。
Microbiol Spectr. 2023 Dec 12;11(6):e0112523. doi: 10.1128/spectrum.01125-23. Epub 2023 Oct 10.
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Multiple phylogenetically-diverse, differentially-virulent Burkholderia pseudomallei isolated from a single soil sample collected in Thailand.
从泰国采集的一个土壤样本中分离出多种进化上不同、毒力不同的伯克霍尔德氏菌假单胞菌。
PLoS Negl Trop Dis. 2022 Feb 10;16(2):e0010172. doi: 10.1371/journal.pntd.0010172. eCollection 2022 Feb.
4
Antibiotic susceptibility of clinical isolates in northeast Thailand during 2015-2018 and the genomic characterization of β-lactam-resistant isolates.2015 - 2018年泰国东北部临床分离株的抗生素敏感性及β-内酰胺耐药分离株的基因组特征
Antimicrob Agents Chemother. 2023 May 1;95(5). doi: 10.1128/AAC.02230-20. Epub 2021 Feb 16.
5
Burkholderia pseudomallei acquired ceftazidime resistance due to gene duplication and amplification.伯克霍尔德氏菌由于基因重复和扩增获得了头孢他啶耐药性。
Int J Antimicrob Agents. 2019 May;53(5):582-588. doi: 10.1016/j.ijantimicag.2019.01.003. Epub 2019 Jan 9.
6
Transcriptional and post-transcriptional regulation of PenA β-lactamase in acquired Burkholderia pseudomallei β-lactam resistance.获得性伯克霍尔德菌假单胞菌β-内酰胺酶对青霉素 A 耐药的转录和转录后调控。
Sci Rep. 2018 Jul 13;8(1):10652. doi: 10.1038/s41598-018-28843-7.
7
Antibiotic Resistance Markers in Burkholderia pseudomallei Strain Bp1651 Identified by Genome Sequence Analysis.通过基因组序列分析鉴定的伯克霍尔德菌假鼻疽亚种Bp1651中的抗生素抗性标记
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