VIII Department of General and Gastrointestinal Surgery, School of Medicine, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy.
World J Gastroenterol. 2011 Aug 7;17(29):3431-40. doi: 10.3748/wjg.v17.i29.3431.
To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal achalasia.
Fifty-six patients (26 men, 30 women; mean age 42.8 ± 14.7 years) presenting for minimally invasive surgery for oesophageal achalasia, were enrolled. All patients underwent laparoscopic Heller myotomy followed by a 180° anterior partial fundoplication in 30 cases (group 1) and calibrated Nissen-Rossetti fundoplication in 26 (group 2). Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication. A 6-mo follow-up period with symptomatic evaluation and barium swallow was undertaken. One and two years after surgery, the patients underwent symptom questionnaires, endoscopy, oesophageal manometry and 24 h oesophago-gastric pH monitoring.
At the 2-year follow-up, no significant difference in the median symptom score was observed between the 2 groups (P = 0.66; Mann-Whitney U-test). The median percentage time with oesophageal pH < 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group (2; range 0.8-10 vs 0.35; range 0-2) (P < 0.0001; Mann-Whitney U-test).
Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of dysphagia. Nissen-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure.
比较腹腔镜校准尼森-罗塞蒂胃底折叠术与 Heller 肌切开术后 Dor 胃底折叠术治疗食管失弛缓症的中期结果。
56 例(26 例男性,30 例女性;平均年龄 42.8±14.7 岁)因微创治疗食管失弛缓症而接受手术的患者入组。所有患者均接受腹腔镜 Heller 肌切开术,然后在 30 例患者中进行 180°前部分胃底折叠术(第 1 组),在 26 例患者中进行校准尼森-罗塞蒂胃底折叠术(第 2 组)。术中胃镜和测压术用于校准肌切开术和胃底折叠术。在 6 个月的随访期内进行症状评估和钡餐检查。手术后 1 年和 2 年,患者接受症状问卷、内窥镜检查、食管测压和 24 小时食管胃 pH 监测。
在 2 年的随访中,两组患者的中位症状评分无显著差异(P = 0.66;Mann-Whitney U 检验)。与尼森-罗塞蒂组相比,Dor 组食管 pH 值<4 的时间百分比明显更高(2;范围 0.8-10 与 0.35;范围 0-2)(P <0.0001;Mann-Whitney U 检验)。
腹腔镜 Dor 胃底折叠术和校准尼森-罗塞蒂胃底折叠术在缓解吞咽困难方面取得了相似的结果。尼森-罗塞蒂胃底折叠术在抑制食管酸暴露方面似乎更有效。