Thune P, Nilsen T, Hanstad I K, Gustavsen T, Lövig Dahl H
Department of Dermatology, Ullevål Hospital, University of Oslo, Norway.
Acta Derm Venereol. 1988;68(4):277-83.
Clinical dryness of the skin is a common problem among elderly, dermatological patients. In the present investigation, hydration, surface lipids, skin pH and water barrier function as expressed by the transepidermal water loss (TEWL) were studied in both dry and normal skin. Using these parameters, a comparison of the local effects of acid and alkaline cleansing products was made. In non-atopic elderly patients with dry skin, the TEWL values were lower than in the younger control group but higher than in the older controls. Following one week's topical therapy, the TEWL values in the patient group decreased further and approached the lower values of the older control group. At the same time the skin hydration values increased, indicating a beneficial effect on the skin barrier. An inverse relationship was demonstrated between TEWL and skin hydration. The study indicates that high TEWL values are frequently correlated with high pH, low hydration of the stratum corneum and reduced skin surface lipid content. Despite the intensive use of an acid syndet and lotion, the pH-readings increased but were still within the 'confidence limits' of the control groups.
临床上皮肤干燥是老年人及皮肤病患者中常见的问题。在本研究中，对干性皮肤和正常皮肤的水合作用、表面脂质、皮肤pH值以及经表皮水分流失（TEWL）所表达的皮肤屏障功能进行了研究。利用这些参数，对酸性和碱性清洁产品的局部效果进行了比较。在非特应性干性皮肤老年患者中，TEWL值低于年轻对照组，但高于老年对照组。经过一周的局部治疗后，患者组的TEWL值进一步降低，并接近老年对照组的较低值。同时皮肤水合值增加，表明对皮肤屏障有有益作用。TEWL与皮肤水合之间呈负相关。研究表明，高TEWL值常与高pH值、角质层低水合作用以及皮肤表面脂质含量降低相关。尽管大量使用了酸性合成洗涤剂和洗剂，但pH读数仍有所升高，但仍在对照组的“置信区间”内。
