Vazquez-Prieto Marcela Alejandra, Rodriguez Lanzi Cecilia, Lembo Carina, Galmarini Claudio Rómulo, Miatello Roberto Miguel
Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, 5500 Mendoza, Argentina.
J Nutr Metab. 2011;2011:475216. doi: 10.1155/2011/475216. Epub 2011 Aug 25.
This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables.
本研究评估了大蒜（G）和洋葱（O）对喂食果糖的大鼠（FFR）的抗氧化和抗炎特性。将30日龄雄性Wistar大鼠分为对照组（C）、F组（饮用水中含10%果糖）、F+T组（1 mM tempol作为对照抗氧化剂）、F+G组和F+O组。大蒜和洋葱的水提取物分别以150和400 mg/kg/d的剂量口服给药，并与tempol一起在14周周期的最后8周给予。在研究结束时，FFR出现了胰岛素抵抗、主动脉NADPH氧化酶活性、收缩压升高、血浆丙二醛和肠系膜动脉中血管细胞粘附分子-1（VCAM-1）表达增加，以及心脏内皮型一氧化氮合酶（eNOS）降低。给F组大鼠服用大蒜和洋葱可降低氧化应激，增加eNOS活性，并减弱VCAM-1表达。这些结果提供了新的证据，表明这些蔬菜具有抗炎和抗氧化作用。
