Gielen Evelien, Boonen Steven, Vanderschueren Dirk, Sinnesael Mieke, Verstuyf Annemieke, Claessens Frank, Milisen Koen, Verschueren Sabine
Division of Geriatric Medicine, Leuven University Hospital, Herestraat 49, 3000 Leuven, Belgium.
J Osteoporos. 2011;2011:875249. doi: 10.4061/2011/875249. Epub 2011 Aug 25.
Calcium and vitamin D supplements reverse secondary hyperparathyroidism and are widely prescribed to prevent osteoporotic fractures, with proven antifracture efficacy when targeted to individuals with documented insufficiencies. Men who should particularly be considered for calcium and vitamin D supplements include elderly or institutionalized individuals, patients with documented osteoporosis on antiresorptive or anabolic medication, and individuals receiving glucocorticoids. Benefits are most apparent when a daily dose of 1000-1200 mg calcium is complemented with 800 IU vitamin D. Compliance is the key to optimizing clinical efficacy. While (conventionally dosed) vitamin D has not been associated with safety concerns, recent meta-analytic data have provided evidence to suggest that calcium supplements (without coadministered vitamin D) may potentially be associated with cardiovascular risks.
钙和维生素D补充剂可逆转继发性甲状旁腺功能亢进，并且广泛用于预防骨质疏松性骨折，针对有明确不足的个体，其抗骨折疗效已得到证实。特别应考虑补充钙和维生素D的男性包括老年人或住在养老院的人、正在接受抗吸收或促合成药物治疗且有记录的骨质疏松症患者，以及正在接受糖皮质激素治疗的个体。当每日补充1000 - 1200毫克钙并辅以800国际单位维生素D时，益处最为明显。依从性是优化临床疗效的关键。虽然（常规剂量的）维生素D未出现安全性问题，但最近的荟萃分析数据表明，钙补充剂（未同时补充维生素D）可能与心血管风险有关。
