Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Clinics (Sao Paulo). 2011;66(7):1203-8. doi: 10.1590/s1807-59322011000700014.
The aim of this study was to investigate the role of the interleukin-18 +105A/C and interleukin-10 -1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis.
We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months (mean 76.10 ± 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 +105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10 -1082A/G polymorphism.
Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower 131I cumulative dose and did not present lymph node metastases.
We conclude that the inheritance of a G allele at the interleukin-10 -1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.
本研究旨在探讨白细胞介素-18+105A/C 和白细胞介素-10-1082A/G 种系多态性在分化型甲状腺癌的发生和转归中的作用，以及是否与同时存在的甲状腺炎有关。
我们研究了 346 例分化型甲状腺癌患者，包括 292 例乳头状癌和 54 例滤泡状癌，根据标准方案进行了 12-298 个月（平均 76.10±68.23 个月）的随访。我们对 200 例患者和 144 例对照个体进行了白细胞介素-18+105A/C 多态性的基因分型，对 183 例患者和 137 例对照个体进行了白细胞介素-10-1082A/G 多态性的基因分型。
白细胞介素-18 多态性与慢性淋巴细胞性甲状腺炎或肿瘤侵袭性的任何临床或病理特征无关。然而，白细胞介素-10 变异体的存在与慢性淋巴细胞性甲状腺炎有关。分化型甲状腺癌患者中慢性淋巴细胞性甲状腺炎的发生率为 21.74%，最常影响先前被诊断为桥本甲状腺炎的女性，这些患者接受了较低的 131I 累积剂量，且无淋巴结转移。
我们的结论是，白细胞介素-10-1082A/G 多态性中 G 等位基因的遗传可能有利于分化型甲状腺癌患者同时发生自身免疫，这种自身免疫可能有利于这些患者的预后。
