Ramos Ana Maria de Oliveira, Sales Alexandre de Oliveira, Barbalho de Mello Luis Eduardo, Cirino de Andrade Márcia, Pinto Paiva Fernando, Ramos Carlos Cesar Oliveira, de Carvalho Formiga Maria Célia, de Formiga Ramos Carlos Cesar, de Matos Patricia Sabino, Ward Laura Sterian
Death Verification Service of the State of Rio G rande do Norte, Natal, Rio Grande do Norte.
Int J Surg Pathol. 2009 Dec;17(6):432-7. doi: 10.1177/1066896909333749. Epub 2009 Apr 29.
Rio Grande do Norte (RN) shows the highest relative incidence of papillary carcinomas in Brazil. To analyze histological features that might be associated with this incidence, the authors compared thyroid glands from 463 autopsies performed in RN with 427 surgical and autopsy glands previously studied in Sao Paulo (SP). The authors found 41 papillary thyroid microcarcinomas (PTMs) in 35 glands (8.1%), an incidence similar to the one reported in SP (7.8%). However, PTMs were predominantly nonencapsulated nonsclerosing at microscopy (44.0%), in contrast with SP where these types of lesion represented only 4 out of 32 PTMs (12.5%; P = .0046). The authors suggest that these nonencapsulated lesions with no sign of inflammation may represent an early stage that may evolve to clinical cancers, contributing to the high incidence of clinically differentiated thyroid carcinomas observed in RN.
北里奥格兰德州（RN）的甲状腺乳头状癌相对发病率在巴西最高。为分析可能与该发病率相关的组织学特征，作者将在RN进行的463例尸检甲状腺与之前在圣保罗（SP）研究的427例手术及尸检甲状腺进行了比较。作者在35个腺体中发现了41例甲状腺微小乳头状癌（PTM）（8.1%），这一发病率与SP报道的发病率（7.8%）相似。然而，在显微镜下，PTM主要为无包膜非硬化型（44.0%），相比之下，在SP这些类型的病变在32例PTM中仅占4例（12.5%；P = 0.0046）。作者认为，这些无炎症迹象的无包膜病变可能代表了一个可能发展为临床癌症的早期阶段，这导致了在RN观察到的临床分化型甲状腺癌的高发病率。
