从芸香科九里香中分离得到的咔唑生物碱诱导 HL-60 白血病细胞凋亡。
Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia.
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
出版信息
J Nat Med. 2012 Apr;66(2):357-61. doi: 10.1007/s11418-011-0584-0. Epub 2011 Aug 31.
We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.
我们对从芸香科植物九里香（Murraya euchrestifolia）中分离得到的 13 种咔唑生物碱进行了初步筛选，以检测它们对人白血病细胞系 HL-60 的细胞生长抑制作用。其中，由于 caspase-9/caspase-3 途径的激活介导的细胞凋亡，murrayafoline-A（1）和 murrayazolinine（7）表现出显著的生长抑制作用。
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