海洋生物碱代谢途径的新见解：重新探讨奥里定生物合成。
New insight into marine alkaloid metabolic pathways: revisiting oroidin biosynthesis.
机构信息
LCMBA UMR 6001 CNRS, Institut de Chimie de Nice, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France.
出版信息
Chembiochem. 2011 Oct 17;12(15):2298-301. doi: 10.1002/cbic.201100449. Epub 2011 Aug 31.
PMID:21882331
Abstract
Sponge natural product biosynthesis: A highly sensitive in vivo protocol based on (14)C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of the origin of the pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline and lysine are now proposed as the early precursors of the pyrrole and the 2-aminoimidazole moieties of oroidin respectively.
摘要
海绵天然产物生物合成
一种基于（14）C 放射性标记前体和β-imager 放射自显影术的高灵敏度体内方案，使得解开了吡咯 2-氨基咪唑含关键生物合成中间体奥里定的起源之谜。脯氨酸和赖氨酸现在分别被提议为奥里定的吡咯和 2-氨基咪唑部分的早期前体。
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