Department of Restorative Dentistry, Cork University Dental School and Hospital, Wilton, Ireland.
J Clin Periodontol. 2011 Oct;38(10):894-901. doi: 10.1111/j.1600-051X.2011.01764.x. Epub 2011 Aug 24.
To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.
A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.
pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.
Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.
确定牙周炎对 2 型糖尿病患者氧化/炎症状态和糖尿病控制的影响。
对 20 例患有牙周炎的 2 型糖尿病患者（BMI 31+5）、20 例年龄/性别匹配的无牙周炎 2 型糖尿病对照者（BMI 29+6）和 20 例非糖尿病牙周炎对照者（BMI 25+4）进行了比较研究，采集牙周检查和空腹血样。通过血浆小分子抗氧化能力（pSMAC）和蛋白质羰基水平来确定氧化应激；通过总/分叶白细胞、纤维蛋白原和高敏 C 反应蛋白（hsCRP）来确定炎症状态；通过空腹血糖、HbA1c、血脂谱、胰岛素抵抗和分泌来确定糖尿病状态。使用 SPSS 进行统计分析。
与无牙周炎的 2 型糖尿病患者相比，患有牙周炎的 2 型糖尿病患者的 pSMAC 更低（p=0.03），蛋白质羰基更高（p=0.007）。牙周炎与糖尿病患者的 HbA1c（p=0.002）和空腹血糖水平（p=0.04）显著升高以及β细胞功能（HOMA-β；p=0.01）降低有关。牙周炎对炎症标志物或血脂谱几乎没有影响，但患有牙周炎的 2 型糖尿病患者的 hsCRP 水平高于无糖尿病患者（p=0.004），且所有组中 HDL-胆固醇水平最低。
牙周炎与 2 型糖尿病患者的氧化应激增加和血糖控制受损有关。
