Akalin Ferda Alev, Işiksal Eda, Baltacioğlu Esra, Renda Nurten, Karabulut Erdem
Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
Arch Oral Biol. 2008 Jan;53(1):44-52. doi: 10.1016/j.archoralbio.2007.07.009. Epub 2007 Sep 18.
Antioxidant defence reduces in diabetes mellitus (DM) and periodontitis. This study investigates antioxidant enzyme; superoxide dismutase (SOD) activity in gingiva and blood glucose and lipid levels in type-2 DM patients and systemically healthy individuals with chronic periodontitis (CP).
Periodontal parameters, blood glycated-haemoglobin (HbA1c), glucose and lipid levels, and gingival-SOD activities (spectrophotometric assay) were measured in 17 DM patients with CP (DMCP), 17 systemically healthy CP patients, 18 periodontally healthy DM patients (DMPH), and 17 healthy controls (PH).
Periodontal parameters were higher in periodontitis groups than the controls (p<0.05), while there was no difference between the periodontitis groups and between the control groups. HbA1c, glucose, and triglyceride levels were higher in diabetic groups than the non-diabetic groups (p<0.05). Low-density lipoprotein (LDL), very-LDL and cholesterol values of the DMCP group did not significantly differ from the CP group. No differences existed between diabetic patients with and without periodontitis in HbA1c, glucose, and lipid levels and the same was true for non-diabetic patients with and without periodontitis. Gingival-SOD activity was lower in periodontitis groups than the matched control groups (p<0.05). DMPH group had the highest and CP group had the lowest SOD levels. There were correlations between periodontal parameters, gingival-SOD activity, HbA1c, glucose and high-density lipoprotein (HDL) levels.
The results suggest that gingival-SOD activity increases in diabetes and decreases in periodontitis and relations may exist between gingival-SOD activity, periodontal status, HbA1c, glucose and HDL levels. The higher gingival-SOD activity in diabetes may be attributed to an adaptive mechanism in the tissue.
抗氧化防御在糖尿病（DM）和牙周炎中会降低。本研究调查抗氧化酶；超氧化物歧化酶（SOD）在2型糖尿病患者和患有慢性牙周炎（CP）的全身健康个体的牙龈中的活性以及血糖和血脂水平。
对17名患有CP的DM患者（DMCP）、17名全身健康的CP患者、18名牙周健康的DM患者（DMPH）和17名健康对照者（PH）测量牙周参数、血液糖化血红蛋白（HbA1c）、血糖和血脂水平以及牙龈SOD活性（分光光度法测定）。
牙周炎组的牙周参数高于对照组（p<0.05），而牙周炎组之间以及对照组之间没有差异。糖尿病组的HbA1c、血糖和甘油三酯水平高于非糖尿病组（p<0.05）。DMCP组的低密度脂蛋白（LDL）、极低密度脂蛋白和胆固醇值与CP组没有显著差异。患有和未患有牙周炎的糖尿病患者在HbA1c、血糖和血脂水平上没有差异，患有和未患有牙周炎的非糖尿病患者也是如此。牙周炎组的牙龈SOD活性低于匹配的对照组（p<0.05）。DMPH组的SOD水平最高，CP组的最低。牙周参数、牙龈SOD活性、HbA1c、血糖和高密度脂蛋白（HDL）水平之间存在相关性。
结果表明，牙龈SOD活性在糖尿病中升高，在牙周炎中降低，并且牙龈SOD活性、牙周状况、HbA1c、血糖和HDL水平之间可能存在关联。糖尿病中较高的牙龈SOD活性可能归因于组织中的一种适应性机制。
