Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.
Science. 2011 Sep 2;333(6047):1244-8. doi: 10.1126/science.1207084.
A major goal of synthetic biology is to develop a deeper understanding of biological design principles from the bottom up, by building circuits and studying their behavior in cells. Investigators initially sought to design circuits "from scratch" that functioned as independently as possible from the underlying cellular system. More recently, researchers have begun to develop a new generation of synthetic circuits that integrate more closely with endogenous cellular processes. These approaches are providing fundamental insights into the regulatory architecture, dynamics, and evolution of genetic circuits and enabling new levels of control across diverse biological systems.
合成生物学的一个主要目标是通过构建电路并研究其在细胞中的行为，从底层向上深入了解生物设计原则。研究人员最初试图设计能够尽可能独立于基础细胞系统运作的“从头开始”的电路。最近，研究人员开始开发新一代与内源性细胞过程更紧密结合的合成电路。这些方法为遗传电路的调控架构、动态和进化提供了基本的见解，并在各种生物系统中实现了新的控制水平。
