Purcell Oliver, Lu Timothy K
MIT Synthetic Biology Center, 500 Technology Square, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
MIT Synthetic Biology Center, 500 Technology Square, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Curr Opin Biotechnol. 2014 Oct;29:146-55. doi: 10.1016/j.copbio.2014.04.009. Epub 2014 May 8.
Biological computation is a major area of focus in synthetic biology because it has the potential to enable a wide range of applications. Synthetic biologists have applied engineering concepts to biological systems in order to construct progressively more complex gene circuits capable of processing information in living cells. Here, we review the current state of computational genetic circuits and describe artificial gene circuits that perform digital and analog computation. We then discuss recent progress in designing gene networks that exhibit memory, and how memory and computation have been integrated to yield more complex systems that can both process and record information. Finally, we suggest new directions for engineering biological circuits capable of computation.
生物计算是合成生物学的一个主要研究领域,因为它有潜力实现广泛的应用。合成生物学家已将工程概念应用于生物系统,以构建能够在活细胞中处理信息的日益复杂的基因电路。在此,我们综述了计算遗传电路的当前状态,并描述了执行数字和模拟计算的人工基因电路。然后,我们讨论了在设计具有记忆功能的基因网络方面的最新进展,以及记忆和计算是如何整合以产生既能处理又能记录信息的更复杂系统的。最后,我们提出了设计具有计算能力的生物电路的新方向。