Wong George K C, Graham Colin A, Ng Elsie, Yeung Janice H H, Rainer Timothy H, Poon Wai S
Department of Surgery, Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.
J Emerg Trauma Shock. 2011 Jul;4(3):346-50. doi: 10.4103/0974-2700.83861.
We aimed to investigate neurological outcomes in elderly patients with multiple trauma, and to review their clinical outcomes following neurosurgical operations.
The study was conducted in a regional trauma center in Hong Kong. We collected prospective data on consecutive trauma patients from January 2001 to December 2008. Patients with multiple trauma (as defined by Injury Severity Score of 15 or more), with both head injury and extracranial injury, were included for analysis.
Age over 65 years, admission Glasgow Coma Scale (GCS), and Injury Severity Score were significantly poor prognostic factors in logistic regression analysis. Eleven (32%) of the 34 patients aged over 65 who underwent neurosurgical operations attained favorable neurological outcomes (GCS 4-5) at 6 months.
Age was an important prognostic factor in multiple trauma patients requiring neurosurgical operations. Future randomized controlled clinical trials should be designed to recruit elderly patients (such as age between 65 and 75 years) at clinical equipoise for traumatic hematoma (such as subdural hematoma or traumatic intracerebral hematoma) evacuation and assess the quality of life, neurological, and cognitive outcomes.
我们旨在研究老年多发伤患者的神经学转归,并回顾其神经外科手术后的临床结局。
本研究在香港一家地区创伤中心开展。我们收集了2001年1月至2008年12月连续创伤患者的前瞻性数据。纳入分析的患者为多发伤(损伤严重度评分15分及以上)且同时合并颅脑损伤和颅外损伤者。
在逻辑回归分析中,年龄超过65岁、入院时格拉斯哥昏迷量表(GCS)评分及损伤严重度评分是显著的不良预后因素。34例年龄超过65岁且接受神经外科手术的患者中,11例(32%)在6个月时获得了良好的神经学转归(GCS 4 - 5分)。
年龄是需要接受神经外科手术的多发伤患者的重要预后因素。未来应设计随机对照临床试验,纳入处于临床 equipoise 状态的老年患者(如年龄在65至75岁之间),针对创伤性血肿(如硬膜下血肿或创伤性脑内血肿)进行清除,并评估生活质量、神经学及认知结局。 (注:equipoise 这个词在医学语境中可能较难准确翻译,这里保留英文未翻译,因为没有完全对应的中文术语且不影响整体理解,如果有更准确的医学术语要求,可进一步探讨。)