Department of Internal Medicine, University Hospital Yalgado Ouédraogo, Ouagadougou, Burkina Faso.
Clin Rheumatol. 2011 Dec;30(12):1617-21. doi: 10.1007/s10067-011-1831-1. Epub 2011 Sep 2.
The objective of this work was to study the clinical and serological profiles of rheumatoid arthritis in Burkina Faso (West Africa). It is a cross-sectional study conducted from March 2006 to February 2009 in the Internal Medicine Department of the University Hospital Yalgado Ouedraogo. All patients seen in the rheumatologic consultation unit during this period, with rheumatoid arthritis fulfilling the ACR criteria, were routinely selected. The determination of anticyclic citrullinated peptide antibodies (ACPA) was carried out with a computerized method (Elia CCP, Phadia AB, Uppsala, Sweden). Values higher than 10 IU/l were considered positive. Forty-eight cases of rheumatoid arthritis (RA) were recruited throughout the study period among 2,194 (2.2 %) patients. Forty-two files were subjected to the study. There were 34 women and 8 men. The average age was 41.70 ± 13 years with extremes of 22 and 71 years. The average duration of the disease was 86.17 ± 82.01 months with extremes of 8 and 360 months. Rheumatoid factors (RF) were positive in 21 out of 30 patients (70.0%). The determination of ACPA carried out in all the patients was positive in 34 (81%) patients; their average value was 217 IU/l with extremes of 38 and 1,170. RF and ACPA were associated to bones erosions (p = 0.0001). Twenty-two patients were placed on methotrexate, eight on hydroxychloroquine, and three on salazopyrine. Nine were given only NSAIDs or prednisolone. No patients had had a biotherapy agent. The frequency of RA was low in our study compared to other African studies published so far. The particularity of RA cases reported in African series, including ours, is the rarity of extra-articular manifestations of the disease. The severity of the disease at presentation in the rheumatology clinic may be due to their late consultation among other causes.
这项工作的目的是研究布基纳法索（西非）类风湿关节炎的临床和血清学特征。这是一项 2006 年 3 月至 2009 年 2 月在 Yalgado Ouedraogo 大学医院内科进行的横断面研究。在此期间，在风湿科门诊就诊并符合 ACR 标准的所有类风湿关节炎患者均被常规选择。环瓜氨酸肽抗体（ACPA）的测定采用计算机方法（Elia CCP，Phadia AB，Uppsala，瑞典）进行。高于 10IU/L 的值被认为是阳性。在整个研究期间，在 2194 名（2.2%）患者中招募了 48 例类风湿关节炎（RA）患者。42 份病历进行了研究。其中 34 名女性和 8 名男性。平均年龄为 41.70±13 岁，极值为 22 岁和 71 岁。平均病程为 86.17±82.01 个月，极值为 8 个月和 360 个月。30 名患者中有 21 名（70.0%）类风湿因子（RF）阳性。对所有患者进行的 ACPA 测定均为阳性，有 34 例（81%）患者；其平均数值为 217IU/L，极值为 38 和 1170。RF 和 ACPA 与骨侵蚀有关（p=0.0001）。22 名患者接受甲氨蝶呤治疗，8 名患者接受羟氯喹治疗，3 名患者接受柳氮磺胺吡啶治疗。9 名患者仅接受 NSAIDs 或泼尼松龙治疗。没有患者接受过生物治疗药物。与迄今为止发表的其他非洲研究相比，我们的研究中 RA 的频率较低。在包括我们在内的非洲系列报告的 RA 病例中，疾病的关节外表现罕见是其特点。在风湿科门诊就诊时疾病的严重程度可能是由于其他原因导致他们就诊较晚。
