用于控释的可见光和pH响应型聚合物包覆介孔二氧化硅纳米杂化物
Visible Light and pH Responsive Polymer-Coated Mesoporous Silica Nanohybrids for Controlled Release.
作者信息
Wang Guojie, Dong Jie, Yuan Tingting, Zhang Juchen, Wang Lei, Wang Hao
机构信息
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
出版信息
Macromol Biosci. 2016 Jul;16(7):990-4. doi: 10.1002/mabi.201600008. Epub 2016 Mar 3.
A visible light and pH responsive anticancer drug delivery system based on polymer-coated mesoporous silica nanoparticles (MSNs) has been developed. Perylene-functionalized poly(dimethylaminoethyl methacrylates) sensitive to visible light and pH are electrostatically attached on the surface of MSNs to seal the nanopores. Stimulation of visible light and acid can unseal the nanopores to induce controlled drug release from the MSNs. More interestingly, the release can be enhanced under the combined stimulation of the dual-stimuli. The synergistic effect of visible light and acid stimulation on the efficient release of anticancer drugs from the nanohybrids endows the system with great potential for cancer therapy.
基于聚合物包覆介孔二氧化硅纳米颗粒（MSNs）开发了一种可见光和pH响应型抗癌药物递送系统。对可见光和pH敏感的苝功能化聚（甲基丙烯酸二甲氨基乙酯）通过静电作用附着在MSNs表面以封闭纳米孔。可见光和酸刺激可打开纳米孔，诱导药物从MSNs中可控释放。更有趣的是，在双重刺激的联合作用下释放可增强。可见光和酸刺激对纳米杂化物中抗癌药物高效释放的协同作用赋予该系统巨大的癌症治疗潜力。
Zotero 插件