Department of Physiology and the Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA,
J Mol Cell Cardiol. 2012 Apr;52(4):840-7. doi: 10.1016/j.yjmcc.2011.08.018. Epub 2011 Aug 26.
Diseases of the coronary circulation remain the leading cause of death in Western society despite impressive advances in diagnosis, pharmacotherapy and post-event management. Part of this statistic likely stems from a parallel increase in the prevalence of obesity and metabolic dysfunction, both significant risk factors for coronary disease. Obesity and diabetes pose unique challenges for the heart and their impact on the coronary vasculature remains incompletely understood. The vascular endothelium is a major interface between arterial function and the physical and chemical components of blood flow. Proper function of the endothelium is necessary to preserve hemostasis, maintain vascular tone and limit the extent of vascular diseases such as atherosclerosis. Given its central role in vascular health, endothelial dysfunction has been the source of considerable research interest in diabetes and obesity. In the current review, we will examine the pathologic impact of obesity and diabetes on coronary function and the extent to which these two factors impact endothelial function. This article is part of a Special Issue entitled "Coronary Blood Flow".
尽管在诊断、药物治疗和事件后管理方面取得了令人瞩目的进展，但冠状动脉循环疾病仍然是西方社会的主要死亡原因。这一统计数据的部分原因可能源于肥胖和代谢功能障碍的患病率同时增加，这两者都是冠心病的重要危险因素。肥胖和糖尿病给心脏带来了独特的挑战，它们对冠状动脉血管的影响仍不完全清楚。血管内皮是动脉功能与血流的物理和化学成分之间的主要界面。内皮的正常功能对于维持止血、维持血管张力和限制动脉粥样硬化等血管疾病的发生范围是必要的。鉴于其在血管健康中的核心作用，内皮功能障碍一直是糖尿病和肥胖症研究的重要关注点。在当前的综述中，我们将研究肥胖和糖尿病对冠状动脉功能的病理影响，以及这两个因素对内皮功能的影响程度。本文是题为“冠状动脉血流”的特刊的一部分。
