Khedr Naglaa F, Ebeid Abla M, Khalil Rania M
Biochemistry Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Clinical Pharmacy Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasaa, Egypt.
Endocrine. 2020 Jan;67(1):109-116. doi: 10.1007/s12020-019-02127-0. Epub 2019 Nov 13.
Orlistat which is taken by obese patients may present some therapeutic assistance through its inhibition of lipase activity. Otherwise, a natural lipase inhibitor as cinnamon is widely used traditional medicine to decrease cholesterol and body weight. The current study aimed to investigate the weight management of orlistat in comparison with cinnamon through different obesity related targets.
Subjects were divided into: Group 1: subjects received cinnamon capsules for 60 days. Group 2: subjects were received orlistat twice daily for 30 days, then once daily for another 30 days. Blood samples were collected at baseline and after 2 months.
Both orlistat and cinnamon groups showed a significant reduction in BMI, lipid profile, and lipase activity compared with baseline. Orlistat group showed significant elevation (p < 0.001) in glucagon, insulin-degrading enzyme (IDE) and dopamine level concomitant with the decrease of serum glutamate compared with baseline level of the same group and cinnamon group. However, cinnamon reduced serum insulin level and insulin resistance (IR) compared with baseline level of the same group and orlistat group.
Orlistat can be used in weight management not only for its pancreatic lipase inhibition but also, due to its indirect appetite reduction effect through elevated glucagon, IDE and dopamine levels and its inhibitory effect on glutamate neurotransmitter, whereas, cinnamon improves BMI and glycaemic targets.
肥胖患者服用的奥利司他可通过抑制脂肪酶活性提供一些治疗帮助。此外，肉桂作为一种天然脂肪酶抑制剂，是一种广泛用于降低胆固醇和体重的传统药物。本研究旨在通过不同的肥胖相关指标比较奥利司他与肉桂在体重管理方面的效果。
将受试者分为：第1组：受试者服用肉桂胶囊60天。第2组：受试者每天服用两次奥利司他，共30天，然后每天服用一次，再持续30天。在基线期和2个月后采集血样。
与基线相比，奥利司他组和肉桂组的体重指数、血脂谱和脂肪酶活性均显著降低。与同一组和肉桂组的基线水平相比，奥利司他组的胰高血糖素、胰岛素降解酶（IDE）和多巴胺水平显著升高（p < 0.001），同时血清谷氨酸水平降低。然而，与同一组和奥利司他组的基线水平相比，肉桂降低了血清胰岛素水平和胰岛素抵抗（IR）。
奥利司他可用于体重管理，不仅因其对胰腺脂肪酶的抑制作用，还因其通过升高胰高血糖素、IDE和多巴胺水平产生的间接食欲降低作用以及对谷氨酸神经递质的抑制作用；而肉桂则可改善体重指数和血糖指标。
