College of Public Health, Hebei Medical University, and The Second Hospital, Shijiazhuang 050017, China.
Chemosphere. 2011 Oct;85(3):448-53. doi: 10.1016/j.chemosphere.2011.07.073. Epub 2011 Sep 3.
There is a dearth of information on the temporal changes in polychlorinated dibenzodioxin/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) contamination, in both environmental and biological specimens, in China. We compared the concentrations of PCDD/Fs and dl-PCBs in human milk collected in Shijiazhuang, Hebei Province, in northern China in 2002 (n=30) and 2007 (n=20). The level of PCDD/Fs and dl-PCBs showed an increasing trend. The mean concentrations of PCDD/Fs plus dl-PCBs were 4.47 TEQ pg g(-1) fat and 6.24 TEQ pg g(-1) fat in human milk from Shijiazhuang in 2002 and in 2007, respectively. Based on statistical analysis of questionnaire data collected by in-person interviews with mothers, we found positive correlations between consumption of sea fish and PCDFs. The PCDDs, PCDFs, PCDD/Fs, and PCDD/Fs plus dl-PCBs levels in individuals consuming greater amounts of sea fish were higher than those consuming less sea fish, both with and without adjustments for potential confounding factors. Among 17 congeners of PCDD/Fs, the 2,3,7,8-TCDF, 1,2,3,7,8-PeCDF, 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, 1,2,3,6,7,8-HxCDF, and 2,3,4,6,7,8-HxCDF congener concentrations in 2007 increased 134%, 55%, 53%, 57%, 65% and 130% when compared to 2002 levels, respectively. The 2007 dl-PCB congener levels were greater than those of the 2002 samples, with the exception of PCB81 and PCB77. Specifically, PCB105, PCB114, PCB118, PCB123 and PCB156 had increased greater than twofold from 2002 to 2007. Continuous surveillance of PCDD/F and dl-PCB levels in human milk is needed to accurately evaluate both environmental contamination and the human health risk to neonates in China.
在中国，有关环境和生物样本中多氯二苯并对二恶英/呋喃（PCDD/Fs）和类似二恶英的多氯联苯（dl-PCBs）污染的时间变化的信息十分匮乏。我们比较了 2002 年（n=30）和 2007 年（n=20）采集于中国河北省石家庄市的人乳中 PCDD/Fs 和 dl-PCBs 的浓度。PCDD/Fs 和 dl-PCBs 的水平呈上升趋势。2002 年和 2007 年，石家庄市人乳中 PCDD/Fs 和 dl-PCBs 的浓度分别为 4.47 TEQ pg g(-1) 脂肪和 6.24 TEQ pg g(-1) 脂肪。基于对母亲进行面对面访谈收集的问卷数据的统计分析，我们发现食用海鱼与 PCDFs 之间存在正相关关系。食用较多海鱼的个体体内的 PCDD、PCDF、PCDD/Fs 和 PCDD/Fs+dl-PCBs 水平高于食用较少海鱼的个体，且在调整了潜在混杂因素后仍然如此。在 17 种 PCDD/Fs 同系物中，2,3,7,8-TCDF、1,2,3,7,8-PeCDF、2,3,4,7,8-PeCDF、1,2,3,4,7,8-HxCDF、1,2,3,6,7,8-HxCDF 和 2,3,4,6,7,8-HxCDF 的浓度在 2007 年比 2002 年分别增加了 134%、55%、53%、57%、65%和 130%。与 2002 年相比，2007 年 dl-PCB 同系物的水平更高，除了 PCB81 和 PCB77 之外。具体而言，从 2002 年到 2007 年，PCB105、PCB114、PCB118、PCB123 和 PCB156 的含量增加了两倍以上。需要对人乳中 PCDD/F 和 dl-PCB 水平进行持续监测，以准确评估中国环境污染物和新生儿人类健康风险。
