Division of Cardiology, University of Southern California, Los Angeles, CA, USA.
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Eur J Clin Nutr. 2022 Dec;76(12):1770-1775. doi: 10.1038/s41430-022-01172-9. Epub 2022 Jun 9.
Literature examining the relationship of circulating omega-3 and omega-6 polyunsaturated fatty acids [n-3(ω-3) and n-6 (ω-6) PUFAs] and arterial elasticity in large cohort-based populations are lacking. We investigated the association of circulating ω-3and ω-6 PUFAs with large artery elasticity (LAE) and small artery elasticity (SAE) in participants from the Multi-Ethnic Study of Atherosclerosis (MESA).
A total of 6124 participants (mean age 61.9; 52% female; 38% White, 27% Black, 22% Hispanic, and 13% Chinese-American) with plasma phospholipid PUFAs and arterial elasticity measured at baseline were included. LAE and SAE were derived from pulse contour analysis of the radial artery in all subjects in a supine position using tonometry. Linear regression models were used to determine associations for levels of (1) each circulating fatty acid, (2) total ω-3PUFAs, and (3) total ω-6 PUFAs with log-transformed LAE and SAE.
Each standard deviation (SD) increment in circulating levels of total ω-3 PUFAs, eicosapentaenoic acid, and docosahexaenoic acid were associated with a 0.017 ml/mmHg, 0.017 ml/mmHg, and 0.015 ml/mmHg higher LAE respectively (p values all <0.01). No significant trends were observed for ω-3 PUFAs levels with SAE.22 Similarly, no significant trends were observed for ω-6 PUFA levels with either LAE or SAE.
In a multi-ethnic cohort of individuals free of baseline cardiovascular disease, higher plasma levels of total and individual ω-3 PUFAs were associated with an increased LAE. Further understanding into differential associations of ω-6 PUFAs with LAE and SAE is needed.
缺乏在大型基于人群的队列中研究循环ω-3 和 ω-6 多不饱和脂肪酸（n-3（ω-3）和 n-6（ω-6）PUFAs）与动脉弹性之间关系的文献。我们在动脉粥样硬化多民族研究（MESA）的参与者中研究了循环ω-3 和 ω-6 PUFAs 与大动脉弹性（LAE）和小动脉弹性（SAE）的相关性。
共纳入 6124 名参与者（平均年龄 61.9 岁；52%为女性；38%为白人，27%为黑人，22%为西班牙裔，13%为华裔），基线时测量了血浆磷脂脂肪酸和动脉弹性。在所有受试者仰卧位时，使用张力计通过桡动脉脉搏轮廓分析得出 LAE 和 SAE。线性回归模型用于确定（1）每种循环脂肪酸、（2）总 ω-3PUFA 和（3）总 ω-6 PUFAs 与 log 转换的 LAE 和 SAE 的水平之间的关联。
循环总 ω-3 PUFAs、二十碳五烯酸和二十二碳六烯酸水平每增加一个标准差（SD），LAE 分别增加 0.017ml/mmHg、0.017ml/mmHg 和 0.015ml/mmHg（p 值均<0.01）。ω-3 PUFAs 水平与 SAE 之间没有观察到明显的趋势。22 同样，ω-6 PUFAs 水平与 LAE 或 SAE 之间也没有观察到明显的趋势。
在一个无基线心血管疾病的多民族队列中，较高的血浆总和个体 ω-3 PUFAs 水平与 LAE 增加相关。需要进一步了解 ω-6 PUFAs 与 LAE 和 SAE 的不同关联。
