Lab. Biotecnología Bacteriana, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN) , CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
J Agric Food Chem. 2011 Oct 12;59(19):10755-60. doi: 10.1021/jf203061p. Epub 2011 Sep 13.
The ability to degrade ochratoxin A was studied in different bacteria with a well-known capacity to transform aromatic compounds. Strains belonging to Rhodococcus, Pseudomonas, and Brevibacterium genera were grown in liquid synthetic culture medium containing ochratoxin A. Brevibacterium spp. strains showed 100% degradation of ochratoxin A. Ochratoxin α was detected and identified by high-performance liquid chromatography-mass spectrometry (HPLC-MS) as a degradation product in the cell-free supernatants. The degradation of ochratoxin A is of public concern for food and environmental safety, because it could contribute to the development of new biological ochratoxin A detoxification systems in foodstuffs. In this study, the degradation of ochratoxin A by bacteria belonging to the food chain was demonstrated for the first time.
研究了具有转化芳香族化合物能力的不同细菌对赭曲霉毒素 A 的降解能力。在含有赭曲霉毒素 A 的液体合成培养基中培养属于红球菌属、假单胞菌属和短杆菌属的菌株。短杆菌属菌株对赭曲霉毒素 A 的降解率达到 100%。高效液相色谱-质谱联用（HPLC-MS）检测到细胞上清液中有赭曲霉毒素 α，被鉴定为降解产物。赭曲霉毒素 A 的降解引起了人们对食品和环境安全的关注，因为它可能有助于开发食品中新型的生物赭曲霉毒素 A 解毒系统。在这项研究中，首次证明了食物链中的细菌对赭曲霉毒素 A 的降解作用。
