Mendes Edmar Lacerda, Ribeiro Andaki Alynne Christian, Brito Ciro José, Córdova Cláudio, Natali Antônio José, Santos Amorim Paulo Roberto Dos, de Oliveira Leandro Licursi, de Paula Sérgio Oliveira, Mutimura Eugene
Programa de Pós-Graduação em Biologia Celular e Estrutural, Laboratório de Imunovirologia Molecular, Universidade Federal de Viçosa/MG, Brasil.
J Med Case Rep. 2011 Sep 5;5:430. doi: 10.1186/1752-1947-5-430.
Lipodystrophy is common in patients infected with human immunodeficiency virus receiving highly active antiretroviral therapy, and presents with morphologic changes and metabolic alterations that are associated with depressive behavior and reduced quality of life. We examined the effects of exercise training on morphological changes, lipid profile and quality of life in a woman with human immunodeficiency virus presenting with lipodystrophy.
A 31-year-old Latin-American Caucasian woman infected with human immunodeficiency virus participated in a 12-week progressive resistance exercise training program with an aerobic component. Her weight, height, skinfold thickness, body circumferences, femur and humerus diameter, blood lipid profile, maximal oxygen uptake volume, exercise duration, strength and quality of life were assessed pre-exercise and post-exercise training. After 12 weeks, she exhibited reductions in her total subcutaneous fat (18.5%), central subcutaneous fat (21.0%), peripheral subcutaneous fat (10.7%), waist circumference (WC) (4.5%), triglycerides (9.9%), total cholesterol (12.0%) and low-density lipoprotein cholesterol (8.6%). She had increased body mass (4.6%), body mass index (4.37%), humerus and femur diameter (3.0% and 2.3%, respectively), high-density lipoprotein cholesterol (16.7%), maximal oxygen uptake volume (33.3%), exercise duration (37.5%) and strength (65.5%). Quality of life measures improved mainly for psychological and physical measures, independence and social relationships.
These findings suggest that supervised progressive resistance exercise training is a safe and effective treatment for evolving morphologic and metabolic disorders in adults infected with HIV receiving highly active antiretroviral therapy, and improves their quality of life.
脂肪代谢障碍在接受高效抗逆转录病毒治疗的人类免疫缺陷病毒（HIV）感染者中很常见，表现为形态学改变和代谢异常，这些与抑郁行为及生活质量下降有关。我们研究了运动训练对一名患脂肪代谢障碍的HIV感染女性的形态学改变、血脂水平及生活质量的影响。
一名31岁感染HIV的拉丁裔白种女性参加了一项为期12周的包含有氧运动成分的渐进性抗阻运动训练计划。在运动训练前及训练后，对她的体重、身高、皮褶厚度、身体周长、股骨和肱骨直径、血脂水平、最大摄氧量、运动时长、力量及生活质量进行了评估。12周后，她的总皮下脂肪减少了18.5%，中央皮下脂肪减少了21.0%，外周皮下脂肪减少了10.7%，腰围减少了4.5%，甘油三酯减少了9.9%，总胆固醇减少了12.0%，低密度脂蛋白胆固醇减少了8.6%。她的体重增加了4.6%，体重指数增加了4.37%，肱骨和股骨直径分别增加了3.0%和2.3%，高密度脂蛋白胆固醇增加了16.7%，最大摄氧量增加了33.3%，运动时长增加了37.5%，力量增加了65.5%。生活质量测量结果主要在心理和身体指标、独立性及社会关系方面得到改善。
这些发现表明，在接受高效抗逆转录病毒治疗的HIV感染成人中，有监督的渐进性抗阻运动训练是治疗正在发展的形态学和代谢紊乱的一种安全有效的方法，并能改善他们的生活质量。
